| 产品: | CSTF1 抗体 |
| 货号: | DF3241 |
| 描述: | Rabbit polyclonal antibody to CSTF1 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 48 KD; 48kD(Calculated). |
| 蛋白号: | Q05048 |
| RRID: | AB_2835621 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3241, RRID:AB_2835621.
展开/折叠
CF 1 50 kDa subunit; CF-1 50 kDa subunit; Cleavage stimulation factor 50 kDa subunit; Cleavage stimulation factor 50kDa subunit; Cleavage stimulation factor; Cleavage stimulation factor subunit 1; Cleavage stimulation factor, 3 prime pre RNA, subunit 1, 50 kD; cleavage stimulation factor, 3' pre RNA, subunit 1, 50kD; cleavage stimulation factor, 3' pre RNA, subunit 1, 50kDa; CstF 50; CSTF 50 kDa subunit; CstF-50; CSTF1; CSTF1_HUMAN; CstFp50; OTTHUMP00000031332;
抗原和靶标
- Q05048 CSTF1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MYRTKVGLKDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMENDDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRSTTD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q05048 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T63 | Phosphorylation | Uniprot | |
| Y67 | Phosphorylation | Uniprot | |
| Y195 | Phosphorylation | Uniprot | |
| K198 | Ubiquitination | Uniprot | |
| K204 | Ubiquitination | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| K316 | Ubiquitination | Uniprot | |
| K319 | Ubiquitination | Uniprot | |
| K326 | Ubiquitination | Uniprot | |
| T364 | Phosphorylation | Uniprot | |
| Y367 | Phosphorylation | Uniprot | |
| S393 | Phosphorylation | Uniprot |
研究背景
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA.
The N-terminus is blocked.
Nucleus.
Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). Interacts (via repeats WD) directly with CSTF3. Interacts (via repeat WD6) with BARD1. Interacts with ERCC6.
N-terminus mediates homodimerization.
研究领域
· Genetic Information Processing > Translation > mRNA surveillance pathway.
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