| 产品: | MMP15 抗体 |
| 货号: | AF0213 |
| 描述: | Rabbit polyclonal antibody to MMP15 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 预测: | Bovine, Horse, Sheep, Dog, Chicken |
| 分子量: | 80kDa, 70 kDa; 76kD(Calculated). |
| 蛋白号: | P51511 |
| RRID: | AB_2833283 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0213, RRID:AB_2833283.
展开/折叠
AI503551; Matrix metallopeptidase 15 membrane inserted; Matrix metalloproteinase 15; Matrix metalloproteinase-15; Membrane type 2 matrix metalloproteinase; Membrane type matrix metalloproteinase 2; Membrane-type matrix metalloproteinase 2; Membrane-type-2 matrix metalloproteinase; MMP 15; MMP-15; MMP15; MMP15_HUMAN; MT MMP 2; MT-MMP 2; MT2 MMP; MT2-MMP; MT2MMP; MTMMP 2; MTMMP2; SMCP 2; SMCP-2; SMCP2;
抗原和靶标
Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.
- P51511 MMP15_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGSDPSAPGRPGWTGSLLGDREEAARPRLLPLLLVLLGCLGLGVAAEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKSILRDFMGCQEHVEPGPRWPDVARPPFNPHGGAEPGADSAEGDVGDGDGDFGAGVNKDGGSRVVVQMEEVARTVNVVMVLVPLLLLLCVLGLTYALVQMQRKGAPRVLLYCKRSLQEWV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P51511 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S67 | Phosphorylation | Uniprot | |
| T305 | O-Glycosylation | Uniprot | |
| T313 | O-Glycosylation | Uniprot | |
| T318 | O-Glycosylation | Uniprot | |
| T320 | O-Glycosylation | Uniprot | |
| K388 | Ubiquitination | Uniprot | |
| S551 | Phosphorylation | Uniprot | |
| S589 | Phosphorylation | Uniprot | |
| Y660 | Phosphorylation | Uniprot | |
| K662 | Ubiquitination | Uniprot |
研究背景
Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.
The precursor is cleaved by a furin endopeptidase.
Membrane>Single-pass type I membrane protein>Extracellular side.
Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Belongs to the peptidase M10A family.
限制条款
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