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产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3344, RRID:AB_2835711.
展开/折叠
AATYK 2; AATYK2; Apoptosis associated tyrosine kinase 2; Apoptosis-associated tyrosine kinase 2; Brain enriched kinase; Brain-enriched kinase; BREK; CDK5/p35 regulated kinase; CDK5/p35-regulated kinase; CPRK; cyclin-dependent kinase 5/p35-regulated kinase; FLJ46659; hBREK; KIAA1079; Kinase phosphatase inhibitor 2; Kinase/phosphatase/inhibitor 2; KPI 2; KPI-2; KPI2; Lemur tyrosine kinase 2; LMR 2; LMR2; LMTK 2; Lmtk2; LMTK2_HUMAN; PPP1R100; protein phosphatase 1, regulatory subunit 100; Serine/threonine protein kinase KPI 2; Serine/threonine protein kinase KPI2; Serine/threonine protein kinase LMTK 2; Serine/threonine protein kinase LMTK2; Serine/threonine-protein kinase KPI-2; Serine/threonine-protein kinase LMTK2;
抗原和靶标
- Q8IWU2 LMTK2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPGPPALRRRLLLLLLVLLIAGSAGAAPLPQTGAGEAPPAAEVSSSFVILCVCSLIILIVLIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLSPEKRPAAEDVHRLLTYLRLQSQRDSEVDFEQQWNALKPNTNSRDSSNNAAFPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWEAAKHDHFDERSRGHLDEGLSYTSIFYPVEVFESSLSDPGPGKQDDSGQDVPLRVPGVVPVFDAHNLSVGSDYYIQLEEKSGSNLELDYPPALLTTDMDNPERTGPELSQLTALRSVELEESSTDEDFFQSSTDPKDSSLPGDLHVTSGPESPFNNIFNDVDKSEDLPSHQKIFDLMELNGVQADFKPATLSSSLDNPKESVITGHFEKEKPRKIFDSEPLCLSDNLMHQDNFDPLNVQELSENFLFLQEKNLLKGSLSSKEHINDLQTELKNAGFTEAMLETSCRNSLDTELQFAENKPGLSLLQENVSTKGDDTDVMLTGDTLSTSLQSSPEVQVPPTSFETEETPRRVPPDSLPTQGETQPTCLDVIVPEDCLHQDISPDAVTVPVEILSTDARTHSLDNRSQDSPGESEETLRLTESDSVLADDILASRVSVGSSLPELGQELHNKPFSEDHHSHRRLEKNLEAVETLNQLNSKDAAKEAGLVSALSSDSTSQDSLLEDSLSAPFPASEPSLETPDSLESVDVHEALLDSLGSHTPQKLVPPDKPADSGYETENLESPEWTLHPAPEGTADSEPATTGDGGHSGLPPNPVIVISDAGDGHRGTEVTPETFTAGSQGSYRDSAYFSDNDSEPEKRSEEVPGTSPSALVLVQEQPLPEPVLPEQSPAAQDSCLEARKSQPDESCLSALHNSSDLELRATPEPAQTGVPQQVHPTEDEASSPWSVLNAELSSGDDFETQDDRPCTLASTGTNTNELLAYTNSALDKSLSSHSEGPKLKEPDIEGKYLGKLGVSGMLDLSEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDETEHPVPIILSNEDGRHLRSLLKPTAANAPDPLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELGPCGGEACGPDLSGPAPASGSPYLSRCINSESSTDEEGGGFEWDDDFSPDPFMSKTTSNLLSSKPSLQTSKYFSPPPPARSTEQSWPHSAPYSRFSISPANIASFSLTHLTDSDIEQGGSSEDGEKD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q8IWU2 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T90 | Phosphorylation | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| K223 | Ubiquitination | Uniprot | |
| K292 | Ubiquitination | Uniprot | |
| S418 | Phosphorylation | Uniprot | |
| K430 | Ubiquitination | Uniprot | |
| S473 | Phosphorylation | Uniprot | |
| Y476 | Phosphorylation | Uniprot | |
| S490 | Phosphorylation | Uniprot | |
| Y500 | Phosphorylation | Uniprot | |
| S525 | Phosphorylation | Uniprot | |
| T582 | Phosphorylation | Uniprot | |
| S587 | Phosphorylation | Uniprot | |
| S594 | Phosphorylation | Uniprot | |
| T602 | Phosphorylation | Uniprot | |
| S630 | Phosphorylation | Uniprot | |
| S671 | Phosphorylation | Uniprot | |
| S679 | Phosphorylation | Uniprot | |
| S788 | Phosphorylation | Uniprot | |
| T876 | Phosphorylation | Uniprot | |
| S883 | Phosphorylation | Uniprot | |
| S886 | Phosphorylation | Uniprot | |
| S901 | Phosphorylation | Uniprot | |
| S955 | Phosphorylation | Uniprot | |
| T996 | Phosphorylation | Uniprot | |
| S1012 | Phosphorylation | Uniprot | |
| T1088 | Phosphorylation | Uniprot | |
| Y1100 | Phosphorylation | Uniprot | |
| S1107 | Phosphorylation | Uniprot | |
| S1111 | Phosphorylation | Uniprot | |
| S1117 | Phosphorylation | Uniprot | |
| T1123 | Phosphorylation | Uniprot | |
| S1124 | Phosphorylation | Uniprot | |
| S1126 | Phosphorylation | Uniprot | |
| S1248 | Phosphorylation | Uniprot | |
| S1251 | Phosphorylation | Uniprot | |
| S1291 | Phosphorylation | Uniprot | |
| S1294 | Phosphorylation | Uniprot | |
| S1305 | Phosphorylation | Uniprot | |
| S1307 | Phosphorylation | Uniprot | |
| S1308 | Phosphorylation | Uniprot | |
| S1310 | Phosphorylation | Uniprot | |
| S1397 | Phosphorylation | Uniprot | |
| T1445 | Phosphorylation | Uniprot | |
| S1446 | Phosphorylation | Uniprot | |
| Y1448 | Phosphorylation | Uniprot | |
| S1450 | Phosphorylation | Q00535 (CDK5) | Uniprot |
| S1465 | Phosphorylation | Uniprot | |
| Y1468 | Phosphorylation | Uniprot | |
| S1489 | Phosphorylation | Uniprot | |
| S1496 | Phosphorylation | Uniprot | |
| S1497 | Phosphorylation | Uniprot |
翻译修饰 - Q8IWU2 作为激酶
研究背景
Phosphorylates PPP1C, phosphorylase b and CFTR.
Autophosphorylated. Phosphorylated (By similarity).
Membrane>Multi-pass membrane protein.
Mainly expressed in skeletal muscle, and weakly in brain and pancreas.
Interacts with PPP1C and inhibitor-2.
Belongs to the protein kinase superfamily. Tyr protein kinase family.
文献引用
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