| 产品: | AZI2 抗体 |
| 货号: | DF3437 |
| 描述: | Rabbit polyclonal antibody to AZI2 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig |
| 分子量: | 48 KD; 45kD(Calculated). |
| 蛋白号: | Q9H6S1 |
| RRID: | AB_2835737 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3437, RRID:AB_2835737.
展开/折叠
5 azacytidine induced protein 2; 5-azacytidine-induced protein 2; AA410145; AZ2; AZI2; AZI2_HUMAN; MGC112644; Nak associated protein 1; Nak-associated protein 1; NAP1; NF kappa B activating kinase associated protein 1; NF-kappa-B-activating kinase-associated protein 1; TILP; TILP(S);
抗原和靶标
- Q9H6S1 AZI2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDALVEDDICILNHEKAHKRDTVTPVSIYSGDESVASHFALVTAYEDIKKRLKDSEKENSLLKKRIRFLEEKLIARFEEETSSVGREQVNKAYHAYREVCIDRDNLKSKLDKMNKDNSESLKVLNEQLQSKEVELLQLRTEVETQQVMRNLNPPSSNWEVEKLSCDLKIHGLEQELELMRKECSDLKIELQKAKQTDPYQEDNLKSRDLQKLSISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIKKACAPVGCSEDLGRDSTKLHLMNFTATYTRHPPLLPNGKALCHTTSSPLPGDVKVLSEKAILQSWTDNERSIPNDGTCFQEHSSYGRNSLEDNSWVFPSPPKSSETAFGETKTKTLPLPNLPPLHYLDQHNQNCLYKN
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9H6S1 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S83 | Phosphorylation | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| K122 | Ubiquitination | Uniprot | |
| K131 | Ubiquitination | Uniprot | |
| T140 | Phosphorylation | Uniprot | |
| T144 | Phosphorylation | Uniprot | |
| S155 | Phosphorylation | Uniprot | |
| S156 | Phosphorylation | Uniprot | |
| K162 | Ubiquitination | Uniprot | |
| S164 | Phosphorylation | Uniprot | |
| K192 | Ubiquitination | Uniprot | |
| K194 | Ubiquitination | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| S213 | Phosphorylation | Uniprot | |
| T249 | Phosphorylation | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| T251 | Phosphorylation | Uniprot | |
| K255 | Ubiquitination | Uniprot | |
| S263 | Phosphorylation | Uniprot | |
| S270 | Phosphorylation | Uniprot | |
| K293 | Ubiquitination | Uniprot | |
| S300 | Phosphorylation | Uniprot | |
| S301 | Phosphorylation | Uniprot | |
| K313 | Ubiquitination | Uniprot | |
| S318 | Phosphorylation | Uniprot | |
| S325 | Phosphorylation | Uniprot | |
| S338 | Phosphorylation | Uniprot | |
| S343 | Phosphorylation | Uniprot | |
| S348 | Phosphorylation | Uniprot | |
| S353 | Phosphorylation | Uniprot | |
| K356 | Ubiquitination | Uniprot | |
| S357 | Phosphorylation | Uniprot |
研究背景
Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1.
Cytoplasm.
Widely expressed. Abundant expression seen in the pancreas and testis.
Homodimer (By similarity). Interacts with IKBKE. Interacts with TBK1. Interacts with TICAM1.
(Microbial infection) Interacts with vaccinia virus protein C6.
研究领域
· Organismal Systems > Immune system > RIG-I-like receptor signaling pathway. (View pathway)
限制条款
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