| 产品: | GRK7 抗体 |
| 货号: | DF3370 |
| 描述: | Rabbit polyclonal antibody to GRK7 |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 62 KD; 62kD(Calculated). |
| 蛋白号: | Q8WTQ7 |
| RRID: | AB_2835752 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3370, RRID:AB_2835752.
展开/折叠
G protein coupled receptor kinase 7; G protein coupled receptor kinase GRK7; G protein-coupled receptor kinase 7; G protein-coupled receptor kinase GRK7; GPRK 7; GPRK7; GRK 7; GRK7; GRK7_HUMAN;
抗原和靶标
- Q8WTQ7 GRK7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVDMGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLCEQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPGNPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELNDPNRPTGCEEGNSSKSGVCLLL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q8WTQ7 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S23 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S36 | Phosphorylation | P17612 (PRKACA) , P17252 (PRKCA) | Uniprot |
| T85 | Phosphorylation | Uniprot | |
| K229 | Acetylation | Uniprot | |
| K230 | Acetylation | Uniprot | |
| K234 | Acetylation | Uniprot | |
| K433 | Acetylation | Uniprot | |
| S490 | Phosphorylation | Q8WTQ7 (GRK7) | Uniprot |
研究背景
Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).
Autophosphorylated in vitro at Ser-490. Phosphorylation at Ser-36 is regulated by light and activated by cAMP.
Membrane>Lipid-anchor.
Retinal cones, outer and inner segments.
Interacts (when prenylated) with PDE6D; this promotes release from membranes.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
研究领域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Organismal Systems > Immune system > Chemokine signaling pathway. (View pathway)
· Organismal Systems > Sensory system > Phototransduction.
限制条款
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