产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3377, RRID:AB_2835759.
展开/折叠
breast cancer-associated antigen SGA-56M; C1orf16; EST1 like protein C; EST1 telomerase component homolog C; EST1-like protein C; EST1C; ever shorter telomeres 1C; FLJ23717; hSMG-7; nonsense mediated mRNA decay factor (C. elegans); Protein SMG7; SGA56M; SMG 7; SMG-7 homolog; Smg7; SMG7_HUMAN;
抗原和靶标
- Q92540 SMG7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLQSAQYLRQAEVLKADMTDSKLGPAEVWTSRQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQGQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSSQLGIISNKQTHTSAIVKPQSSSCSYICQHCLVHLGDIARYRNQTSQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSKALESRDEVKTKWGVSDFIKAFIKFHGHVYLSKSLEKLSPLREKLEEQFKRLLFQKAFNSQQLVHVTVINLFQLHHLRDFSNETEQHTYSQDEQLCWTQLLALFMSFLGILCKCPLQNESQEESYNAYPLPAVKVSMDWLRLRPRVFQEAVVDERQYIWPWLISLLNSFHPHEEDLSSISATPLPEEFELQGFLALRPSFRNLDFSKGHQGITGDKEGQQRRIRQQRLISIGKWIADNQPRLIQCENEVGKLLFITEIPELILEDPSEAKENLILQETSVIESLAADGSPGLKSVLSTSRNLSNNCDTGEKPVVTFKENIKTREVNRDQGRSFPPKEVRRDYSKGITVTKNDGKKDNNKRKTETKKCTLEKLQETGKQNVAVQVKSQTELRKTPVSEARKTPVTQTPTQASNSQFIPIHHPGAFPPLPSRPGFPPPTYVIPPPVAFSMGSGYTFPAGVSVPGTFLQPTAHSPAGNQVQAGKQSHIPYSQQRPSGPGPMNQGPQQSQPPSQQPLTSLPAQPTAQSTSQLQVQALTQQQQSPTKAVPALGKSPPHHSGFQQYQQADASKQLWNPPQVQGPLGKIMPVKQPYYLQTQDPIKLFEPSLQPPVMQQQPLEKKMKPFPMEPYNHNPSEVKVPEFYWDSSYSMADNRSVMAQQANIDRRGKRSPGVFRPEQDPVPRMPFEKSLLEKPSELMSHSSSFLSLTGFSLNQERYPNNSMFNEVYGKNLTSSSKAELSPSMAPQETSLYSLFEGTPWSPSLPASSDHSTPASQSPHSSNPSSLPSSPPTHNHNSVPFSNFGPIGTPDNRDRRTADRWKTDKPAMGGFGIDYLSATSSSESSWHQASTPSGTWTGHGPSMEDSSAVLMESLKSIWSSSMMHPGPSALEQLLMQQKQKQQRGQGTMNPPH
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q92540 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| K16 | Ubiquitination | Uniprot | |
| K23 | Ubiquitination | Uniprot | |
| K42 | Ubiquitination | Uniprot | |
| Y50 | Phosphorylation | Uniprot | |
| K54 | Ubiquitination | Uniprot | |
| K55 | Ubiquitination | Uniprot | |
| K66 | Ubiquitination | Uniprot | |
| K77 | Ubiquitination | Uniprot | |
| K122 | Ubiquitination | Uniprot | |
| K216 | Ubiquitination | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| K232 | Ubiquitination | Uniprot | |
| K243 | Ubiquitination | Uniprot | |
| K264 | Ubiquitination | Uniprot | |
| K268 | Ubiquitination | Uniprot | |
| K275 | Ubiquitination | Uniprot | |
| K438 | Ubiquitination | Uniprot | |
| K447 | Ubiquitination | Uniprot | |
| K464 | Ubiquitination | Uniprot | |
| S520 | Phosphorylation | Uniprot | |
| K524 | Ubiquitination | Uniprot | |
| S528 | Phosphorylation | Uniprot | |
| S534 | Phosphorylation | Uniprot | |
| T539 | Phosphorylation | Uniprot | |
| K542 | Ubiquitination | Uniprot | |
| K581 | Acetylation | Uniprot | |
| K585 | Acetylation | Uniprot | |
| T624 | Phosphorylation | Uniprot | |
| K780 | Ubiquitination | Uniprot | |
| S781 | Phosphorylation | Uniprot | |
| S786 | Phosphorylation | Uniprot | |
| Y791 | Phosphorylation | Uniprot | |
| K798 | Ubiquitination | Uniprot | |
| K812 | Ubiquitination | Uniprot | |
| K817 | Ubiquitination | Uniprot | |
| Y820 | Phosphorylation | Uniprot | |
| K847 | Ubiquitination | Uniprot | |
| K865 | Ubiquitination | Uniprot | |
| S897 | Phosphorylation | Uniprot | |
| R910 | Methylation | Uniprot | |
| S928 | Phosphorylation | Uniprot | |
| S929 | Phosphorylation | Uniprot | |
| S930 | Phosphorylation | Uniprot | |
| S938 | Phosphorylation | Uniprot | |
| R943 | Methylation | Uniprot | |
| Y954 | Phosphorylation | Uniprot | |
| K956 | Ubiquitination | Uniprot | |
| S1075 | Phosphorylation | Uniprot | |
| T1076 | Phosphorylation | Uniprot | |
| S1078 | Phosphorylation | Uniprot | |
| K1123 | Ubiquitination | Uniprot |
研究背景
Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.
Cytoplasm. Nucleus.
Note: Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm.
Part of a complex that contains SMG5, SMG7, PPP2CA, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated UPF1.
研究领域
· Genetic Information Processing > Translation > mRNA surveillance pathway.
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