产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3378, RRID:AB_2835760.
展开/折叠
A kinase anchor protein; A-kinase anchor protein 1; A-kinase anchor protein 149 kDa; AKAP 149; AKAP; Akap1; AKAP1_HUMAN; D-AKAP-1; DAKAP1; Dual specificity A-kinase-anchoring protein 1; mitochondrial; PRKA1; Protein kinase A-anchoring protein 1; Protein kinase A1; S-AKAP84; SAKAP84; Spermatid A-kinase anchor protein 84;
抗原和靶标
Isoform 1 is detected in thymus, prostate, testis, ovary, colon and small intestine (PubMed:8769136). Isoform 2 is highly expressed in testis and detected at much lower levels in kidney, pancreas, liver, lung and brain (PubMed:7499250).
- Q92667 AKAP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAIQFRSLFPLALPGMLALLGWWWFFSRKKGHVSSHDEQQVEAGAVQLRADPAIKEPLPVEDVCPKVVSTPPSVTEPPEKELSTVSKLPAEPPALLQTHPPCRRSESSGILPNTTDMRLRPGTRRDDSTKLELALTGGEAKSIPLECPLSSPKGVLFSSKSAEVCKQDSPFSRVPRKVQPGYPVVPAEKRSSGERARETGGAEGTGDAVLGEKVLEEALLSREHVLELENSKGPSLASLEGEEDKGKSSSSQVVGPVQEEEYVAEKLPSRFIESAHTELAKDDAAPAPPVADAKAQDRGVEGELGNEESLDRNEEGLDRNEEGLDRNEESLDRNEEGLDRNEEIKRAAFQIISQVISEATEQVLATTVGKVAGRVCQASQLQGQKEESCVPVHQKTVLGPDTAEPATAEAAVAPPDAGLPLPGLPAEGSPPPKTYVSCLKSLLSSPTKDSKPNISAHHISLASCLALTTPSEELPDRAGILVEDATCVTCMSDSSQSVPLVASPGHCSDSFSTSGLEDSCTETSSSPRDKAITPPLPESTVPFSNGVLKGELSDLGAEDGWTMDAEADHSGGSDRNSMDSVDSCCSLKKTESFQNAQAGSNPKKVDLIIWEIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGSQHHVDKALNLIGKKFKELNLTNIYAPPLPSLALPSLPMTSWLMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEITVICAAPGADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGAEVLLDSVMPLSDDDQFSPEADAAMSEMTGNTALLAQVTSYSPTGLPLIQLWSVVGDEVVLINRSLVERGLAQWVDSYYTSL
翻译修饰 - Q92667 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K55 | Ubiquitination | Uniprot | |
| C64 | S-Nitrosylation | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| T70 | Phosphorylation | Uniprot | |
| S73 | Phosphorylation | Uniprot | |
| S105 | Phosphorylation | Uniprot | |
| S107 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| S142 | Phosphorylation | Uniprot | |
| S150 | Phosphorylation | Uniprot | |
| S151 | Phosphorylation | Uniprot | |
| S158 | Phosphorylation | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| S161 | Phosphorylation | Uniprot | |
| S169 | Phosphorylation | Uniprot | |
| K213 | Ubiquitination | Uniprot | |
| S231 | Phosphorylation | Uniprot | |
| S235 | Phosphorylation | Uniprot | |
| S238 | Phosphorylation | Uniprot | |
| K266 | Ubiquitination | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| S309 | Phosphorylation | Uniprot | |
| S330 | Phosphorylation | Uniprot | |
| S353 | Phosphorylation | Uniprot | |
| S357 | Phosphorylation | Uniprot | |
| T360 | Phosphorylation | Uniprot | |
| T366 | Phosphorylation | Uniprot | |
| S429 | Phosphorylation | Uniprot | |
| K440 | Methylation | Uniprot | |
| S441 | Phosphorylation | Uniprot | |
| S444 | Phosphorylation | Uniprot | |
| S445 | Phosphorylation | Uniprot | |
| T447 | Phosphorylation | Uniprot | |
| T533 | Phosphorylation | Uniprot | |
| S573 | Phosphorylation | Uniprot | |
| S577 | Phosphorylation | Uniprot | |
| S580 | Phosphorylation | Uniprot | |
| S583 | Phosphorylation | Uniprot | |
| S586 | Phosphorylation | Uniprot | |
| K589 | Ubiquitination | Uniprot | |
| T590 | Phosphorylation | Uniprot | |
| S592 | Phosphorylation | Uniprot | |
| S600 | Phosphorylation | Uniprot | |
| K603 | Ubiquitination | Uniprot | |
| K634 | Ubiquitination | Uniprot | |
| K666 | Ubiquitination | Uniprot | |
| K673 | Ubiquitination | Uniprot | |
| K800 | Ubiquitination | Uniprot | |
| K803 | Ubiquitination | Uniprot | |
| Y900 | Phosphorylation | Uniprot | |
| S902 | Phosphorylation | Uniprot |
研究背景
Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane.
Mitochondrion outer membrane.
Isoform 1 is detected in thymus, prostate, testis, ovary, colon and small intestine. Isoform 2 is highly expressed in testis and detected at much lower levels in kidney, pancreas, liver, lung and brain.
Interacts with SLC8A3.
RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
限制条款
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