| 产品: | PFKFB2 抗体 |
| 货号: | AF0344 |
| 描述: | Rabbit polyclonal antibody to PFKFB2 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 58kDa; 58kD(Calculated). |
| 蛋白号: | O60825 |
| RRID: | AB_2833514 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0344, RRID:AB_2833514.
展开/折叠
6 phosphofructo 2 kinase/ fructose 2,6 bisphosphatase; 6 phosphofructo 2 kinase/fructose 2,6 biphosphatase 3; 6-bisphosphatase; 6-P2ase 3; 6-P2ASE brain/placenta-type isozyme; 6PF 2 K/Fru 2,6 P2ASE brain/placenta type isozyme; 6PF 2-K/Fru 2,6 P2ase 3; 6PF-2-K/Fru-2; F263_HUMAN; fructose 6 phosphate,2 kinase/fructose 2, 6 bisphosphatase; Fructose-2; Inducible 6 phosphofructo 2 kinase/fructose 2,6 bisphosphatase; iPFK 2; iPFK-2; IPFK2; PFK/FBPase 3; PFK2; PFKFB3; Renal carcinoma antigen NY REN 56; Renal carcinoma antigen NY-REN-56; uPFK 2;
抗原和靶标
- O60825 F262_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSGASSSEQNNNSYETKTPNLRMSEKKCSWASYMTNSPTLIVMIGLPARGKTYVSKKLTRYLNWIGVPTKVFNLGVYRREAVKSYKSYDFFRHDNEEAMKIRKQCALVALEDVKAYLTEENGQIAVFDATNTTRERRDMILNFAEQNSFKVFFVESVCDDPDVIAANILEVKVSSPDYPERNRENVMEDFLKRIECYKVTYRPLDPDNYDKDLSFIKVINVGQRFLVNRVQDYIQSKIVYYLMNIHVQPRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFALRDQEKYLYRYPGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTIFKLTPVAYGCKVETIKLNVEAVNTHRDKPTNNFPKNQTPVRMRRNSFTPLSSSNTIRRPRNYSVGSRPLKPLSPLRAQDMQEGAD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O60825 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| S24 | Phosphorylation | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| S84 | Phosphorylation | Uniprot | |
| K86 | Ubiquitination | Uniprot | |
| K103 | Ubiquitination | Uniprot | |
| S175 | Phosphorylation | Uniprot | |
| K192 | Ubiquitination | Uniprot | |
| K211 | Ubiquitination | Uniprot | |
| K279 | Ubiquitination | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| K298 | Ubiquitination | Uniprot | |
| K305 | Ubiquitination | Uniprot | |
| Y356 | Phosphorylation | Uniprot | |
| Y358 | Phosphorylation | Uniprot | |
| Y366 | Phosphorylation | Uniprot | |
| T458 | Phosphorylation | Uniprot | |
| S466 | Phosphorylation | P23443 (RPS6KB1) , Q13131 (PRKAA1) , P31749 (AKT1) , P17612 (PRKACA) , P51812 (RPS6KA3) , P54646 (PRKAA2) | Uniprot |
| T468 | Phosphorylation | Uniprot | |
| S471 | Phosphorylation | Uniprot | |
| S472 | Phosphorylation | Uniprot | |
| T475 | Phosphorylation | Uniprot | |
| Y482 | Phosphorylation | Uniprot | |
| S483 | Phosphorylation | P31749 (AKT1) | Uniprot |
| S486 | Phosphorylation | Uniprot | |
| S493 | Phosphorylation | Uniprot |
研究背景
Synthesis and degradation of fructose 2,6-bisphosphate.
Phosphorylation by AMPK stimulates activity.
Heart.
Homodimer.
In the C-terminal section; belongs to the phosphoglycerate mutase family.
研究领域
· Environmental Information Processing > Signal transduction > AMPK signaling pathway. (View pathway)
· Metabolism > Carbohydrate metabolism > Fructose and mannose metabolism.
· Organismal Systems > Endocrine system > Thyroid hormone signaling pathway. (View pathway)
限制条款
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