产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3408, RRID:AB_2835790.
展开/折叠
52 kDa ribosomal protein S6 kinase; humS6PKh1; KS6C1_HUMAN; Ribosomal protein S6 kinase 52kD polypeptide 1; Ribosomal protein S6 kinase 52kDa polypeptide 1; Ribosomal protein S6 kinase C1; Ribosomal protein S6 kinase delta 1; Ribosomal protein S6 kinase delta-1; Ribosomal S6 kinase like protein with two PSK domains 118 kDa protein; Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein; RPK 118; RPK118; RPS6KC1; RSKL1; S6K-delta-1; S6PKh1; SPHK1 binding protein; SPHK1-binding protein;
抗原和靶标
Highly expressed in testis, skeletal muscle, brain, heart, placenta, kidney and liver and weakly expressed in thymus, small intestine, lung and colon.
- Q96S38 KS6C1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDDGMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFLNRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSSQDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGNGVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEFFRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTISRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGIIENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAAVDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q96S38 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T93 | Phosphorylation | Uniprot | |
| S109 | Phosphorylation | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| S229 | Phosphorylation | Uniprot | |
| K248 | Ubiquitination | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| Y259 | Phosphorylation | Uniprot | |
| S263 | Phosphorylation | Uniprot | |
| Y266 | Phosphorylation | Uniprot | |
| K268 | Ubiquitination | Uniprot | |
| S281 | Phosphorylation | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| T284 | Phosphorylation | Uniprot | |
| S302 | Phosphorylation | Uniprot | |
| S332 | Phosphorylation | Uniprot | |
| T378 | Phosphorylation | Uniprot | |
| S423 | Phosphorylation | Uniprot | |
| S427 | Phosphorylation | Uniprot | |
| K431 | Ubiquitination | Uniprot | |
| T437 | Phosphorylation | Uniprot | |
| S449 | Phosphorylation | Uniprot | |
| S455 | Phosphorylation | Uniprot | |
| S461 | Phosphorylation | Uniprot | |
| S500 | Phosphorylation | Uniprot | |
| S528 | Phosphorylation | Uniprot | |
| S549 | Phosphorylation | Uniprot | |
| S560 | Phosphorylation | Uniprot | |
| K571 | Ubiquitination | Uniprot | |
| S582 | Phosphorylation | Uniprot | |
| S583 | Phosphorylation | Uniprot | |
| S593 | Phosphorylation | Uniprot | |
| S596 | Phosphorylation | Uniprot | |
| S605 | Phosphorylation | Uniprot | |
| K606 | Ubiquitination | Uniprot | |
| S608 | Phosphorylation | Uniprot | |
| S610 | Phosphorylation | Uniprot | |
| K620 | Ubiquitination | Uniprot | |
| Y622 | Phosphorylation | Uniprot | |
| K630 | Ubiquitination | Uniprot | |
| S640 | Phosphorylation | Uniprot | |
| S644 | Phosphorylation | Uniprot | |
| S648 | Phosphorylation | Uniprot | |
| K651 | Ubiquitination | Uniprot | |
| T659 | Phosphorylation | Uniprot | |
| S661 | Phosphorylation | Uniprot | |
| S664 | Phosphorylation | Uniprot | |
| S667 | Phosphorylation | Uniprot | |
| K674 | Ubiquitination | Uniprot | |
| S682 | Phosphorylation | Uniprot | |
| K759 | Ubiquitination | Uniprot | |
| S760 | Phosphorylation | Uniprot | |
| S762 | Phosphorylation | Uniprot | |
| K766 | Ubiquitination | Uniprot | |
| S784 | Phosphorylation | Uniprot | |
| S823 | Phosphorylation | Uniprot | |
| S826 | Phosphorylation | Uniprot | |
| S834 | Phosphorylation | Uniprot | |
| K855 | Ubiquitination | Uniprot | |
| S866 | Phosphorylation | Uniprot | |
| K869 | Ubiquitination | Uniprot | |
| S872 | Phosphorylation | Uniprot | |
| K891 | Ubiquitination | Uniprot |
研究背景
May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell. Plays a role in the recruitment of PRDX3 to early endosomes.
Cytoplasm. Membrane. Early endosome.
Highly expressed in testis, skeletal muscle, brain, heart, placenta, kidney and liver and weakly expressed in thymus, small intestine, lung and colon.
Interacts with SPHK1 and phosphatidylinositol 3-phosphate. Interacts (via PX domain) with PRDX3.
The PX domain is essential for its localization to the early endosomes.
The first protein kinase domain appears to be a pseudokinase domain as it does not contain the classical characteristics, such as the ATP-binding motif, ATP-binding site and active site.
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.
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