| 产品: | ADA2L 抗体 |
| 货号: | AF0347 |
| 描述: | Rabbit polyclonal antibody to ADA2L |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat, Monkey |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 47kDa; 52kD(Calculated). |
| 蛋白号: | O75478 |
| RRID: | AB_2833517 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0347, RRID:AB_2833517.
展开/折叠
ADA2 ALPHA; ADA2; ADA2 like; ADA2 like protein; ADA2, yeast, homolog of, alpha; ADA2A; hADA2; KL04P; Tada2l; Transcriptional adapter 2 alpha; Transcriptional adapter 2 like; Transcriptional adaptor 2 (ADA2 homolog, yeast) like; Transcriptional adaptor 2 (ADA2, yeast, homolog) like; Transcriptional adaptor 2 alpha; Transcriptional adaptor 2A;
抗原和靶标
- O75478 TAD2A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDRLGPFSNDPSDKPPCRGCSSYLMEPYIKCAECGPPPFFLCLQCFTRGFEYKKHQSDHTYEIMTSDFPVLDPSWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHFINNPLFASTLLNLKQAEEAKTADTAIPFHSTDDPPRPTFDSLLSRDMAGYMPARADFIEEFDNYAEWDLRDIDFVEDDSDILHALKMAVVDIYHSRLKERQRRKKIIRDHGLINLRKFQLMERRYPKEVQDLYETMRRFARIVGPVEHDKFIESHALEFELRREIKRLQEYRTAGITNFCSARTYDHLKKTREEERLKRTMLSEVLQYIQDSSACQQWLRRQADIDSGLSPSIPMASNSGRRSAPPLNLTGLPGTEKLNEKEKELCQMVRLVPGAYLEYKSALLNECNKQGGLRLAQARALIKIDVNKTRKIYDFLIREGYITKG
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O75478 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| P6 | Phosphorylation | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| K138 | Ubiquitination | Uniprot | |
| Y211 | Phosphorylation | Uniprot | |
| S213 | Phosphorylation | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| T253 | Phosphorylation | Uniprot | |
| S361 | Phosphorylation | Uniprot | |
| K375 | Ubiquitination | Uniprot | |
| K381 | Ubiquitination | Uniprot | |
| K398 | Ubiquitination | Uniprot | |
| K407 | Ubiquitination | Uniprot | |
| K421 | Ubiquitination | Uniprot | |
| K429 | Ubiquitination | Uniprot |
研究背景
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
Nucleus. Chromosome.
Expressed in all tissues, but most abundantly in testis.
Interacts with GCN5 and NR3C1. Associated with the P/CAF protein in the PCAF complex. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. Interacts with CCDC134.
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