| 产品: | Mlx 抗体 |
| 货号: | DF3466 |
| 描述: | Rabbit polyclonal antibody to Mlx |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 33 KD; 33kD(Calculated). |
| 蛋白号: | Q9UH92 |
| RRID: | AB_2835830 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3466, RRID:AB_2835830.
展开/折叠
bHLHd13; BigMax protein; Class D basic helix-loop-helix protein 13; MAD7; Max like bHLHZip protein; Max like protein X; Max-like bHLHZip protein; Max-like protein X; MLX; MLX_HUMAN; MLXIP; MONDOA; MXD7; Protein BigMax; Protein Mlx; TCFL4; transcription factor like 4; Transcription factor like protein 4; Transcription factor-like protein 4;
抗原和靶标
Expressed in all tissues tested, including spleen, thymus, prostate, ovary, intestine, colon, peripheral blood leukocyte, heart, liver, skeletal muscle and kidney. Lower levels of expression in testis, brain, placenta and lung.
- Q9UH92 MLX_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTEPGASPEDPWVKASPVGAHAGEGRAGRARARRGAGRRGASLLSPKSPTLSVPRGCREDSSHPACAKVEYAYSDNSLDPGLFVESTRKGSVVSRANSIGSTSASSVPNTDDEDSDYHQEAYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCKPQTLREIVIGVLHQLKNQLY
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9UH92 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S7 | Phosphorylation | Uniprot | |
| R26 | Methylation | Uniprot | |
| R29 | Methylation | Uniprot | |
| R31 | Methylation | Uniprot | |
| S42 | Phosphorylation | Uniprot | |
| S45 | Phosphorylation | Uniprot | |
| S48 | Phosphorylation | Uniprot | |
| T50 | Phosphorylation | Uniprot | |
| S74 | Phosphorylation | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| T87 | Phosphorylation | Uniprot | |
| S91 | Phosphorylation | Uniprot | |
| S94 | Phosphorylation | Uniprot | |
| S98 | Phosphorylation | Uniprot | |
| T102 | Phosphorylation | Uniprot | |
| S105 | Phosphorylation | Uniprot | |
| S106 | Phosphorylation | Uniprot | |
| T110 | Phosphorylation | Uniprot | |
| S115 | Phosphorylation | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| K173 | Ubiquitination | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| K193 | Ubiquitination | Uniprot | |
| T206 | Phosphorylation | Uniprot | |
| K209 | Ubiquitination | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| K220 | Ubiquitination | Uniprot |
研究背景
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.
Cytoplasm.
Note: Found predominantly in the cytoplasm (PubMed:10918583).
Cytoplasm.
Note: Found predominantly in the cytoplasm (PubMed:10918583).
Nucleus.
Note: Found predominantly in the nucleus (PubMed:10918583).
Expressed in all tissues tested, including spleen, thymus, prostate, ovary, intestine, colon, peripheral blood leukocyte, heart, liver, skeletal muscle and kidney. Lower levels of expression in testis, brain, placenta and lung.
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAD1, MAD4, MNT, WBSCR14 and MLXIP. Can also bind DNA as a homodimer.
研究领域
· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.
· Human Diseases > Endocrine and metabolic diseases > Non-alcoholic fatty liver disease (NAFLD).
限制条款
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