| 产品: | 5HT6 Receptor 抗体 |
| 货号: | DF3505 |
| 描述: | Rabbit polyclonal antibody to 5HT6 Receptor |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Dog |
| 分子量: | 47 KD; 47kD(Calculated). |
| 蛋白号: | P50406 |
| RRID: | AB_2835867 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3505, RRID:AB_2835867.
展开/折叠
5 HT 6; 5 HT6; 5 HT6R; 5 hydroxytryptamine (serotonin) receptor 6 G protein coupled; 5 hydroxytryptamine 6 receptor; 5 hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; 5-hydroxytryptamine receptor 6; 5HT 6; 5HT6R_HUMAN; HTR 6; Htr6; Serotonin receptor 6;
抗原和靶标
Expressed in several human brain regions, most prominently in the caudate nucleus.
- P50406 5HT6R_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P50406 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y125 | Phosphorylation | Uniprot | |
| K258 | Methylation | Uniprot | |
| K262 | Methylation | Uniprot | |
| S347 | Phosphorylation | Uniprot |
研究背景
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling.
Cell membrane>Multi-pass membrane protein.
Expressed in several human brain regions, most prominently in the caudate nucleus.
Interacts with MTOR, RPTOR and NF1. Interacts with CDK5 (By similarity).
Belongs to the G-protein coupled receptor 1 family.
研究领域
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Organismal Systems > Nervous system > Serotonergic synapse.
限制条款
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