| 产品: | ADRA1A 抗体 |
| 货号: | DF3506 |
| 描述: | Rabbit polyclonal antibody to ADRA1A |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Rabbit |
| 分子量: | 51 KD; 51kD(Calculated). |
| 蛋白号: | P35348 |
| RRID: | AB_2835868 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3506, RRID:AB_2835868.
展开/折叠
ADA1A_HUMAN; ADRA1A; Adra1c; ADRA1L1; Adrenergic alpha1A receptor; Adrenergic alpha1C receptor; Adrenergic receptor alpha 1a; Adrenergic receptor alpha 1c; Adrenergic, alpha 1A , receptor variant 1; Adrenergic, alpha 1A , receptor variant 11; Adrenergic, alpha 1A , receptor variant 3; Adrenergic, alpha 1A , receptor variant 5; Adrenergic, alpha 1A , receptor variant 8; Adrenoceptor alpha 1A; Alpha 1A adrenoreceptor; Alpha 1C adrenergic receptor; Alpha-1A adrenergic receptor; Alpha-1A adrenoceptor; Alpha-1A adrenoreceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c; Alpha1A adrenergic receptor; ALPHA1AAR; G protein coupled receptor;
抗原和靶标
Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.
- P35348 ADA1A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P35348 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S220 | Phosphorylation | Uniprot | |
| S227 | Phosphorylation | Uniprot | |
| S229 | Phosphorylation | Uniprot | |
| T233 | Phosphorylation | Uniprot | |
| K239 | Acetylation | Uniprot | |
| K239 | Ubiquitination | Uniprot | |
| S246 | Phosphorylation | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| S258 | Phosphorylation | Uniprot | |
| T273 | Phosphorylation | Uniprot | |
| S304 | Phosphorylation | Uniprot | |
| S351 | Phosphorylation | Uniprot | |
| S352 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| T384 | Phosphorylation | Uniprot | |
| S389 | Phosphorylation | Uniprot | |
| S401 | Phosphorylation | Uniprot | |
| S402 | Phosphorylation | Uniprot | |
| S407 | Phosphorylation | Uniprot | |
| T411 | Phosphorylation | Uniprot | |
| S413 | Phosphorylation | Uniprot | |
| T451 | Phosphorylation | Uniprot |
研究背景
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
C-terminal Ser or Thr residues may be phosphorylated.
Nucleus membrane>Multi-pass membrane protein. Cell membrane>Multi-pass membrane protein. Cytoplasm. Membrane>Caveola.
Note: Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.
Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes. Interacts with CAVIN4.
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.
研究领域
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Environmental Information Processing > Signal transduction > AMPK signaling pathway. (View pathway)
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
· Organismal Systems > Circulatory system > Vascular smooth muscle contraction. (View pathway)
· Organismal Systems > Digestive system > Salivary secretion.
限制条款
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