产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0359, RRID:AB_2833524.
展开/折叠
H1 histone family member 0; H1(0); H10; H10_HUMAN; h1f0; H1FV; Histone H1''; Histone H1(0); Histone H1.0; Histone H10; Histone H5; MGC5241; N-terminally processed;
抗原和靶标
- P07305 H10_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTENSTSAPAAKPKRAKASKKSTDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKVGENADSQIKLSIKRLVTTGVLKQTKGVGASGSFRLAKSDEPKKSVAFKKTKKEIKKVATPKKASKPKKAASKAPTKKPKATPVKKAKKKLAATPKKAKKPKTVKAKPVKASKPKKAKPVKPKAKSSAKRAGKKK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P07305 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| T2 | Acetylation | Uniprot | |
| T2 | Phosphorylation | Uniprot | |
| S5 | Phosphorylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| K12 | Methylation | Uniprot | |
| K14 | Acetylation | Uniprot | |
| K27 | Acetylation | Uniprot | |
| K27 | Ubiquitination | Uniprot | |
| K40 | Ubiquitination | Uniprot | |
| K52 | Acetylation | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| Y58 | Phosphorylation | Uniprot | |
| K59 | Acetylation | Uniprot | |
| K59 | Methylation | Uniprot | |
| K59 | Ubiquitination | Uniprot | |
| S66 | Phosphorylation | Uniprot | |
| K82 | Methylation | Uniprot | |
| K82 | Ubiquitination | Uniprot | |
| T84 | Phosphorylation | Uniprot | |
| K85 | Ubiquitination | Uniprot | |
| S90 | Phosphorylation | Uniprot | |
| S92 | Phosphorylation | Uniprot | |
| K102 | Methylation | Uniprot | |
| K108 | Acetylation | Uniprot | |
| K108 | Methylation | Uniprot | |
| T119 | Phosphorylation | Uniprot | |
| K121 | Acetylation | Uniprot | |
| S124 | Phosphorylation | Uniprot | |
| T141 | Phosphorylation | Uniprot | |
| K149 | Ubiquitination | Uniprot | |
| T153 | Phosphorylation | Uniprot | |
| K155 | Methylation | Uniprot | |
| K161 | Acetylation | Uniprot | |
| S171 | Phosphorylation | Uniprot |
研究背景
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.
Phosphorylated on Ser-17 in RNA edited version.
ADP-ribosylated on Ser-104 in response to DNA damage.
Nucleus. Chromosome.
Note: The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.
Belongs to the histone H1/H5 family.
限制条款
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