| 产品: | GBP1 抗体 |
| 货号: | DF3598 |
| 描述: | Rabbit polyclonal antibody to GBP1 |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Horse, Rabbit |
| 分子量: | 68 KD; 68kD(Calculated). |
| 蛋白号: | P32455 |
| RRID: | AB_2835970 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3598, RRID:AB_2835970.
展开/折叠
GBP 1; GBP-1; GBP1; GBP1_HUMAN; GTP binding protein 1; GTP-binding protein 1; Guanine nucleotide binding protein 1; Guanine nucleotide-binding protein 1; Guanylate binding protein 1; Guanylate binding protein 1 interferon inducible 67kDa; Guanylate binding protein 1 interferon inducible; HuGBP 1; HuGBP-1; HuGBP1; Interferon induced guanylate binding protein 1; Interferon-induced guanylate-binding protein 1; OTTHUMP00000012352;
抗原和靶标
- P32455 GBP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAGKKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P32455 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S52 | Phosphorylation | Uniprot | |
| S66 | Phosphorylation | Uniprot | |
| T70 | Phosphorylation | Uniprot | |
| T75 | Phosphorylation | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| S156 | Phosphorylation | Uniprot | |
| S157 | Phosphorylation | Uniprot | |
| T218 | Phosphorylation | Uniprot | |
| K278 | Ubiquitination | Uniprot | |
| Y335 | Phosphorylation | Uniprot | |
| S371 | Phosphorylation | Uniprot | |
| S372 | Phosphorylation | Uniprot | |
| K374 | Ubiquitination | Uniprot | |
| K382 | Ubiquitination | Uniprot | |
| Y427 | Phosphorylation | Uniprot | |
| K453 | Ubiquitination | Uniprot | |
| Y464 | Phosphorylation | Uniprot | |
| S523 | Phosphorylation | Uniprot | |
| K544 | Methylation | Uniprot | |
| K544 | Ubiquitination | Uniprot | |
| K553 | Acetylation | Uniprot | |
| K562 | Acetylation | Uniprot | |
| K562 | Ubiquitination | Uniprot | |
| K573 | Ubiquitination | Uniprot | |
| K582 | Ubiquitination | Uniprot |
研究背景
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.
Isoprenylation is required for proper subcellular location.
Cytoplasm. Golgi apparatus membrane>Lipid-anchor>Cytoplasmic side. Cell membrane. Secreted.
Note: Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of IFNG induction. Golgi membrane localization requires isoprenylation and the presence of another IFNG-induced factor.
Homodimer; homodimerization occurs upon GTP-binding and is required for the second hydrolysis step from GDP to GMP. Heterodimer with other family members, including GBP2, GBP3, GBP4 and GBP5. Dimerization regulates subcellular location to membranous structures.
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
研究领域
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
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