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产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3619, RRID:AB_2835991.
展开/折叠
LAMB2; lamc1; LAMC1_HUMAN; Laminin B2 chain; Laminin subunit gamma-1; Laminin, gamma 1 (formerly LAMB2); Laminin-1 subunit gamma; Laminin-10 subunit gamma; Laminin-11 subunit gamma; Laminin-2 subunit gamma; Laminin-3 subunit gamma; Laminin-4 subunit gamma; Laminin-6 subunit gamma; Laminin-7 subunit gamma; Laminin-8 subunit gamma; Laminin-9 subunit gamma; MGC87297; S-LAM gamma; S-laminin subunit gamma;
抗原和靶标
- P11047 LAMC1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRGSHRAAPALRPRGRLWPVLAVLAAAAAAGCAQAAMDECTDEGGRPQRCMPEFVNAAFNVTVVATNTCGTPPEEYCVQTGVTGVTKSCHLCDAGQPHLQHGAAFLTDYNNQADTTWWQSQTMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISSTFQIDEDGWRAEQRDGSEASLEWSSERQDIAVISDSYFPRYFIAPAKFLGKQVLSYGQNLSFSFRVDRRDTRLSAEDLVLEGAGLRVSVPLIAQGNSYPSETTVKYVFRLHEATDYPWRPALTPFEFQKLLNNLTSIKIRGTYSERSAGYLDDVTLASARPGPGVPATWVESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETCDPETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQECPACYRLVKDKVADHRVKLQELESLIANLGTGDEMVTDQAFEDRLKEAEREVMDLLREAQDVKDVDQNLMDRLQRVNNTLSSQISRLQNIRNTIEETGNLAEQARAHVENTERLIEIASRELEKAKVAAANVSVTQPESTGDPNNMTLLAEEARKLAERHKQEADDIVRVAKTANDTSTEAYNLLLRTLAGENQTAFEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLSPLDSETLENEANNIKMEAENLEQLIDQKLKDYEDLREDMRGKELEVKNLLEKGKTEQQTADQLLARADAAKALAEEAAKKGRDTLQEANDILNNLKDFDRRVNDNKTAAEEALRKIPAINQTITEANEKTREAQQALGSAAADATEAKNKAHEAERIASAVQKNATSTKAEAERTFAEVTDLDNEVNNMLKQLQEAEKELKRKQDDADQDMMMAGMASQAAQEAEINARKAKNSVTSLLSIINDLLEQLGQLDTVDLNKLNEIEGTLNKAKDEMKVSDLDRKVSDLENEAKKQEAAIMDYNRDIEEIMKDIRNLEDIRKTLPSGCFNTPSIEKP
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P11047 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S4 | Phosphorylation | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| K164 | Ubiquitination | Uniprot | |
| T166 | Phosphorylation | Uniprot | |
| S179 | Phosphorylation | Uniprot | |
| S181 | Phosphorylation | Uniprot | |
| T185 | Phosphorylation | Uniprot | |
| S187 | Phosphorylation | Uniprot | |
| K188 | Ubiquitination | Uniprot | |
| T196 | Phosphorylation | Uniprot | |
| S210 | Phosphorylation | Uniprot | |
| T216 | Phosphorylation | Uniprot | |
| T258 | Phosphorylation | O14757 (CHEK1) | Uniprot |
| K268 | Ubiquitination | Uniprot | |
| S272 | Phosphorylation | Uniprot | |
| Y273 | Phosphorylation | Uniprot | |
| Y274 | Phosphorylation | Uniprot | |
| Y275 | Phosphorylation | Uniprot | |
| K302 | Ubiquitination | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| Y413 | Phosphorylation | Uniprot | |
| N650 | N-Glycosylation | Uniprot | |
| S664 | Phosphorylation | Uniprot | |
| Y667 | Phosphorylation | Uniprot | |
| S675 | Phosphorylation | Uniprot | |
| K788 | Ubiquitination | Uniprot | |
| K802 | Ubiquitination | Uniprot | |
| K1093 | Ubiquitination | Uniprot | |
| R1102 | Methylation | Uniprot | |
| N1107 | N-Glycosylation | Uniprot | |
| T1127 | Phosphorylation | Uniprot | |
| S1149 | Phosphorylation | Uniprot | |
| N1161 | N-Glycosylation | Uniprot | |
| N1175 | N-Glycosylation | Uniprot | |
| N1223 | N-Glycosylation | Uniprot | |
| N1241 | N-Glycosylation | Uniprot | |
| S1275 | Phosphorylation | Uniprot | |
| K1303 | Ubiquitination | Uniprot | |
| Y1307 | Phosphorylation | Uniprot | |
| K1329 | Ubiquitination | Uniprot | |
| K1371 | Ubiquitination | Uniprot | |
| N1395 | N-Glycosylation | Uniprot | |
| K1404 | Acetylation | Uniprot | |
| K1466 | Ubiquitination | Uniprot | |
| S1493 | Phosphorylation | Uniprot | |
| T1529 | Phosphorylation | Uniprot | |
| T1541 | Phosphorylation | Uniprot | |
| K1544 | Ubiquitination | Uniprot | |
| K1557 | Ubiquitination | Uniprot | |
| S1559 | Phosphorylation | Uniprot | |
| K1566 | Ubiquitination | Uniprot | |
| K1584 | Ubiquitination | Uniprot | |
| T1603 | O-Glycosylation | Uniprot | |
| S1605 | Phosphorylation | Uniprot |
研究背景
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Secreted>Extracellular space>Extracellular matrix>Basement membrane.
Found in the basement membranes (major component).
Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-1 is a subunit of laminin-1 (laminin-111 or EHS laminin), laminin-2 (laminin-211 or merosin), laminin-3 (laminin-121 or S-laminin), laminin-4 (laminin-221 or S-merosin), laminin-6 (laminin-311 or K-laminin), laminin-7 (laminin-321 or KS-laminin), laminin-8 (laminin-411), laminin-9 (laminin-421), laminin-10 (laminin-511) and laminin-11 (laminin-521).
The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domains VI and IV are globular.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Focal adhesion. (View pathway)
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > ECM-receptor interaction. (View pathway)
· Human Diseases > Neurodegenerative diseases > Prion diseases.
· Human Diseases > Infectious diseases: Parasitic > Toxoplasmosis.
· Human Diseases > Infectious diseases: Parasitic > Amoebiasis.
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Small cell lung cancer. (View pathway)
文献引用
Application: WB Species: Mouse Sample:
限制条款
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