| 产品: | PSMD12 抗体 |
| 货号: | DF3644 |
| 描述: | Rabbit polyclonal antibody to PSMD12 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 50 KD; 53kD(Calculated). |
| 蛋白号: | O00232 |
| RRID: | AB_2836016 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3644, RRID:AB_2836016.
展开/折叠
26S proteasome non-ATPase regulatory subunit 12; 26S proteasome regulatory subunit p55; 26S proteasome regulatory subunit RPN5; MGC75406; p55; proteasome (prosome, macropain) 26S subunit, non ATPase12; Proteasome 26S non ATPase subunit 12 isoform 2; PSD12_HUMAN; PSMD12; Rpn5;
抗原和靶标
- O00232 PSD12_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O00232 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| Y20 | Phosphorylation | Uniprot | |
| S21 | Phosphorylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| K36 | Ubiquitination | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| K92 | Sumoylation | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| K98 | Ubiquitination | Uniprot | |
| K103 | Ubiquitination | Uniprot | |
| Y111 | Phosphorylation | Uniprot | |
| K121 | Ubiquitination | Uniprot | |
| Y137 | Phosphorylation | Uniprot | |
| K147 | Ubiquitination | Uniprot | |
| K153 | Ubiquitination | Uniprot | |
| K160 | Ubiquitination | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| K212 | Acetylation | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| T219 | Phosphorylation | Uniprot | |
| K221 | Acetylation | Uniprot | |
| K221 | Ubiquitination | Uniprot | |
| Y227 | Phosphorylation | Uniprot | |
| C255 | S-Nitrosylation | Uniprot | |
| K262 | Ubiquitination | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| K301 | Ubiquitination | Uniprot | |
| K330 | Ubiquitination | Uniprot | |
| S332 | Phosphorylation | Uniprot | |
| S335 | Phosphorylation | Uniprot | |
| S343 | Phosphorylation | Uniprot | |
| K349 | Ubiquitination | Uniprot | |
| K368 | Acetylation | Uniprot | |
| K368 | Ubiquitination | Uniprot | |
| Y369 | Phosphorylation | Uniprot | |
| Y370 | Phosphorylation | Uniprot | |
| K419 | Ubiquitination | Uniprot | |
| K431 | Ubiquitination | Uniprot | |
| S434 | Phosphorylation | Uniprot | |
| S437 | Phosphorylation | Uniprot | |
| K441 | Ubiquitination | Uniprot | |
| K448 | Acetylation | Uniprot | |
| K448 | Ubiquitination | Uniprot |
研究背景
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD12, a base containing 6 ATPases and few additional components. Interacts with ERCC6.
Belongs to the proteasome subunit p55 family.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > Proteasome.
· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.
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