| 产品: | MAN1B1 抗体 |
| 货号: | AF0386 |
| 描述: | Rabbit polyclonal antibody to MAN1B1 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 分子量: | 80kDa; 80kD(Calculated). |
| 蛋白号: | Q9UKM7 |
| RRID: | AB_2833542 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0386, RRID:AB_2833542.
展开/折叠
Alpha 1 2 mannosidase; Endoplasmic reticulum alpha mannosidase 1; Endoplasmic reticulum mannosyl oligosaccharide 1 2 alpha mannosidase 1; Endoplasmic reticulum mannosyl oligosaccharide 1 2 alpha mannosidase; ER alpha 1 2 mannosidase; Man9GlcNAc2 specific processing alpha mannosidase; MANA ER; Mannosidase alpha class 1B member 1;
抗原和靶标
- Q9UKM7 MA1B1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAACEGRRSGALGSSQSDFLTPPVGGAPWAVATTVVMYPPPPPPPHRDFISVTLSFGENYDNSKSWRRRSCWRKWKQLSRLQRNMILFLLAFLLFCGLLFYINLADHWKALAFRLEEEQKMRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQGTPVHLNYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWILGLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRLMPAFRTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEAVEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQETQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVYHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFFLGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPIWTPA
翻译修饰 - Q9UKM7 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T21 | Phosphorylation | Uniprot | |
| Y60 | Phosphorylation | Uniprot | |
| S63 | Phosphorylation | Uniprot | |
| K129 | Ubiquitination | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| S174 | O-Glycosylation | Uniprot | |
| T204 | O-Glycosylation | Uniprot | |
| T219 | O-Glycosylation | Uniprot | |
| S223 | O-Glycosylation | Uniprot | |
| T230 | O-Glycosylation | Uniprot | |
| T239 | O-Glycosylation | Uniprot | |
| T242 | O-Glycosylation | Uniprot | |
| K275 | Ubiquitination | Uniprot | |
| S341 | Phosphorylation | Uniprot | |
| K354 | Acetylation | Uniprot | |
| K371 | Ubiquitination | Uniprot | |
| T381 | O-Glycosylation | Uniprot | |
| K434 | Ubiquitination | Uniprot | |
| Y487 | Phosphorylation | Uniprot | |
| T508 | O-Glycosylation | Uniprot | |
| T565 | Phosphorylation | Uniprot | |
| Y577 | Phosphorylation | Uniprot | |
| K588 | Ubiquitination | Uniprot | |
| K649 | Ubiquitination | Uniprot |
研究背景
Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2).
Endoplasmic reticulum membrane>Single-pass type II membrane protein.
Widely expressed.
Belongs to the glycosyl hydrolase 47 family.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum. (View pathway)
· Metabolism > Glycan biosynthesis and metabolism > N-Glycan biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
限制条款
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