产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3699, RRID:AB_2836063.
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60S ribosomal protein L17; 60S ribosomal protein L23; FLJ92089; Gene encoding putative NFkB activating protein; L17; MGC117162; PD 1; PD-1; PD1; Ribosomal protein L17; RL17_HUMAN; RPL17; rpL23;
抗原和靶标
A synthesized peptide derived from human RPL17, corresponding to a region within C-terminal amino acids.
Expressed in pancreas, lung, colon, cystic duct, gall bladder, kidney and liver. Expressed at high levels in the well differentiated pancreatic tumor cell lines HPAF, COLO 357 and Capan-1, the moderately differentiated pancreatic tumor cell lines T3M-4, AsPc-1 and BxPc-3, the poorly differentiated pancreatic tumor cell line MIA PaCa-2, and the pancreatic tumor cell lines of undefined differentiation status such as SW979. Expressed at lower levels in the poorly differentiated pancreatic tumor cell lines HCG-25 and PANC-1.
- P18621 RL17_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLQKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P18621 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S5 | Phosphorylation | Uniprot | |
| K13 | Ubiquitination | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| C15 | S-Nitrosylation | Uniprot | |
| K27 | Ubiquitination | Uniprot | |
| K37 | Acetylation | Uniprot | |
| K37 | Methylation | Uniprot | |
| K37 | Sumoylation | Uniprot | |
| K37 | Ubiquitination | Uniprot | |
| K49 | Acetylation | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| K55 | Acetylation | Uniprot | |
| K55 | Ubiquitination | Uniprot | |
| R69 | Methylation | Uniprot | |
| K74 | Acetylation | Uniprot | |
| K74 | Ubiquitination | Uniprot | |
| K85 | Acetylation | Uniprot | |
| K86 | Sumoylation | Uniprot | |
| K86 | Ubiquitination | Uniprot | |
| S87 | Phosphorylation | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| K121 | Ubiquitination | Uniprot | |
| T129 | Phosphorylation | Uniprot | |
| S141 | Phosphorylation | Uniprot | |
| S142 | Phosphorylation | Uniprot | |
| K159 | Sumoylation | Uniprot | |
| K159 | Ubiquitination | Uniprot | |
| K167 | Ubiquitination | Uniprot | |
| S171 | Phosphorylation | Uniprot |
研究背景
Component of the large ribosomal subunit.
Expressed in pancreas, lung, colon, cystic duct, gall bladder, kidney and liver. Expressed at high levels in the well differentiated pancreatic tumor cell lines HPAF, COLO 357 and Capan-1, the moderately differentiated pancreatic tumor cell lines T3M-4, AsPc-1 and BxPc-3, the poorly differentiated pancreatic tumor cell line MIA PaCa-2, and the pancreatic tumor cell lines of undefined differentiation status such as SW979. Expressed at lower levels in the poorly differentiated pancreatic tumor cell lines HCG-25 and PANC-1.
Component of the large ribosomal subunit.
Belongs to the universal ribosomal protein uL22 family.
研究领域
· Genetic Information Processing > Translation > Ribosome.
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