| 产品: | FYCO1 抗体 |
| 货号: | AF0388 |
| 描述: | Rabbit polyclonal antibody to FYCO1 |
| 应用: | WB IHC |
| 反应: | Human, Rat |
| 预测: | Horse |
| 分子量: | 166kDa; 167kD(Calculated). |
| 蛋白号: | Q9BQS8 |
| RRID: | AB_2833543 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0388, RRID:AB_2833543.
展开/折叠
CATC2; CTRCT18; DKFZp779K1152; FLJ13335; FYCO1; FYCO1_HUMAN; FYVE and coiled coil domain containing 1; FYVE and coiled coil domain containing protein 1; FYVE and coiled-coil domain-containing protein 1; MGC126517; MGC126519; RUFY3; RUN and FYVE domain containing 3; ZFYVE7; Zinc finger FYVE domain containing protein 7; Zinc finger FYVE domain-containing protein 7;
抗原和靶标
- Q9BQS8 FYCO1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASTNAESQLQRIIRDLQDAVTELSKEFQEAGEPITDDSTSLHKFSYKLEYLLQFDQKEKATLLGNKKDYWDYFCACLAKVKGANDGIRFVKSISELRTSLGKGRAFIRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLQPKLSSDIVGQLYELTEVQFDLASRGFDLDAAWPTFARRTLTTGSSAYLWKPPSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHCRICGRIFCYYCCNNYVLSKHGGKKERCCRACFQKLSEGPGSPDSSGSGTSQGEPSPALSPASPGPQATGGQGANTDYRPPDDAVFDIITDEELCQIQESGSSLPETPTETDSLDPNAAEQDTTSTSLTPEDTEDMPVGQDSEICLLKSGELMIKVPLTVDEIASFGEGSRELFVRSSTYSLIPITVAEAGLTISWVFSSDPKSISFSVVFQEAEDTPLDQCKVLIPTTRCNSHKENIQGQLKVRTPGIYMLIFDNTFSRFVSKKVFYHLTVDRPVIYDGSDFL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9BQS8 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| T22 | Phosphorylation | Uniprot | |
| S25 | Phosphorylation | Uniprot | |
| K44 | Ubiquitination | Uniprot | |
| K67 | Ubiquitination | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| K129 | Ubiquitination | Uniprot | |
| K193 | Ubiquitination | Uniprot | |
| S196 | Phosphorylation | Uniprot | |
| S268 | Phosphorylation | Uniprot | |
| T276 | Phosphorylation | Uniprot | |
| S342 | Phosphorylation | Uniprot | |
| S367 | Phosphorylation | Uniprot | |
| K416 | Ubiquitination | Uniprot | |
| S547 | Phosphorylation | Uniprot | |
| T603 | Phosphorylation | Uniprot | |
| S609 | Phosphorylation | Uniprot | |
| K623 | Ubiquitination | Uniprot | |
| S662 | Phosphorylation | Uniprot | |
| S735 | Phosphorylation | Uniprot | |
| S849 | Phosphorylation | Uniprot | |
| S878 | Phosphorylation | Uniprot | |
| C882 | S-Nitrosylation | Uniprot | |
| Y1136 | Phosphorylation | Uniprot | |
| S1155 | Phosphorylation | Uniprot | |
| S1343 | Phosphorylation | Uniprot | |
| S1427 | Phosphorylation | Uniprot | |
| Y1472 | Phosphorylation | Uniprot |
研究背景
May mediate microtubule plus end-directed vesicle transport.
Cytoplasmic vesicle>Autophagosome. Endosome. Lysosome.
Note: Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes.
Expressed in heart and skeletal muscle.
Can form homodimers. Interacts (via C-terminus) with MAP1LC3B. Interacts with RAB7A; the interaction with RAB7A induces FYCO1 recruitment to late endosomal/lysosomal compartments. Interacts with MAP1LC3B (By similarity).
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