| 产品: | ACOT2 抗体 |
| 货号: | DF3734 |
| 描述: | Rabbit polyclonal antibody to ACOT2 |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Bovine |
| 分子量: | 53 KD; 53kD(Calculated). |
| 蛋白号: | P49753 |
| RRID: | AB_2836098 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3734, RRID:AB_2836098.
展开/折叠
AA571646; ACOT2; Acyl CoA thioesterase 2; Acyl coenzyme A thioester hydrolase 2a; Acyl coenzyme A thioesterase 2, mitochondrial; CTE Ia; CTE1A; Long chain acyl CoA thioesterase 2; Mitochondrial acyl CoA thioesterase 1; Mitochondrial acyl CoA thioesterase 2; MTE1; Peroxisomal long chain acyl coA; PTE2; PTE2A; ZAP128;
抗原和靶标
Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas.
- P49753 ACOT2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSNKLLSPHPHSVVLRSEFKMASSPAVLRASRLYQWSLKSSAQFLGSPQLRQVGQIIRVPARMAATLILEPAGRCCWDEPVRIAVRGLAPEQPVTLRASLRDEKGALFQAHARYRADTLGELDLERAPALGGSFAGLEPMGLLWALEPEKPLVRLVKRDVRTPLAVELEVLDGHDPDPGRLLCQTRHERYFLPPGVRREPVRVGRVRGTLFLPPEPGPFPGIVDMFGTGGGLLEYRASLLAGKGFAVMALAYYNYEDLPKTMETLHLEYFEEAMNYLLSHPEVKGPGVGLLGISKGGELCLSMASFLKGITAAVVINGSVANVGGTLHYKGETLPPVGVNRNRIKVTKDGYADIVDVLNSPLEGPDQKSFIPVERAESTFLFLVGQDDHNWKSEFYANEACKRLQAHGRRKPQIICYPETGHYIEPPYFPLCRASLHALVGSPIIWGGEPRAHAMAQVDAWKQLQTFFHKHLGGHEGTIPSKV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P49753 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S7 | Phosphorylation | Uniprot | |
| S23 | Phosphorylation | Uniprot | |
| S24 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| T66 | Phosphorylation | Uniprot | |
| R86 | Methylation | Uniprot | |
| K104 | Acetylation | Uniprot | |
| T118 | Phosphorylation | Uniprot | |
| T162 | Phosphorylation | Uniprot | |
| S294 | Phosphorylation | Uniprot | |
| K348 | Ubiquitination | Uniprot | |
| Y351 | Phosphorylation | Uniprot | |
| K368 | Ubiquitination | Uniprot | |
| K402 | Acetylation | Uniprot | |
| K462 | Acetylation | Uniprot | |
| K482 | Ubiquitination | Uniprot |
研究背景
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 2/ACOT2 displays higher activity toward long chain acyl CoAs (C14-C20). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity).
Mitochondrion.
Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas.
Monomer.
Belongs to the C/M/P thioester hydrolase family.
研究领域
· Metabolism > Lipid metabolism > Fatty acid elongation.
· Metabolism > Lipid metabolism > Biosynthesis of unsaturated fatty acids.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Endocrine system > Ovarian steroidogenesis.
限制条款
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