SLC25A6 Antibody - #DF3742
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3742, RRID:AB_2836106.
展开/折叠
AAC3; Adenine nucleotide translocator 3; ADP; ADP ATP carrier protein 3; ADP ATP carrier protein isoform T2; ADP ATP carrier protein liver; ADP/ATP translocase 3; ADP/ATP translocator of liver; ADT3_HUMAN; ANT 2; ANT 3; ANT; ANT3; ANT3Y; ATP carrier protein 3; ATP carrier protein; CDABP0051; isoform T2; MGC17525; SLC25A6; Solute carrier family 25 (mitochondrial carrier adenine nucleotide translocator) member 6; Solute carrier family 25 member 6;
抗原和靶标
- P12236 ADT3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDELKKVI
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P12236 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| T2 | Acetylation | Uniprot | |
| K10 | Acetylation | Uniprot | |
| K10 | Methylation | Uniprot | |
| K10 | Ubiquitination | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| K23 | Acetylation | Uniprot | |
| K23 | Ubiquitination | Uniprot | |
| T24 | Phosphorylation | Uniprot | |
| K33 | Acetylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| S42 | Phosphorylation | Uniprot | |
| K43 | Acetylation | Uniprot | |
| K43 | Ubiquitination | Uniprot | |
| K49 | Methylation | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| Y51 | Phosphorylation | Uniprot | |
| K52 | Methylation | Uniprot | |
| K63 | Acetylation | Uniprot | |
| K63 | Ubiquitination | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| Y81 | Phosphorylation | Uniprot | |
| T84 | Phosphorylation | Uniprot | |
| K92 | Acetylation | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| K94 | Acetylation | Uniprot | |
| K96 | Acetylation | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| K105 | Acetylation | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| Y112 | Phosphorylation | Uniprot | |
| S119 | Phosphorylation | Uniprot | |
| T139 | Phosphorylation | Uniprot | |
| R140 | Methylation | Uniprot | |
| K147 | Acetylation | Uniprot | |
| K147 | Methylation | Uniprot | |
| K147 | Ubiquitination | Uniprot | |
| S148 | Phosphorylation | Uniprot | |
| T150 | Phosphorylation | Uniprot | |
| R155 | Methylation | Uniprot | |
| C160 | S-Nitrosylation | Uniprot | |
| K163 | Acetylation | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| K166 | Ubiquitination | Uniprot | |
| Y191 | Phosphorylation | Uniprot | |
| Y195 | Phosphorylation | Uniprot | |
| T197 | Phosphorylation | Uniprot | |
| K199 | Sumoylation | Uniprot | |
| K199 | Ubiquitination | Uniprot | |
| K206 | Sumoylation | Uniprot | |
| Y229 | Phosphorylation | Uniprot | |
| S242 | Phosphorylation | Uniprot | |
| K245 | Ubiquitination | Uniprot | |
| K260 | Ubiquitination | Uniprot | |
| K268 | Acetylation | Uniprot | |
| K268 | Ubiquitination | Uniprot | |
| K272 | Acetylation | Uniprot | |
| K272 | Methylation | Uniprot | |
| K272 | Ubiquitination | Uniprot | |
| S276 | Phosphorylation | Uniprot |
研究背景
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Trimethylated by ANTKMT at Lys-52.
Mitochondrion inner membrane>Multi-pass membrane protein.
Note: The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria.
Found in a complex with ARL2, ARL2BP and SLC25A6 (By similarity). Homodimer.
(Microbial infection) Interacts with influenza A virus PB1-F2 protein.
(Microbial infection) Interacts with HIV-1 Vpr.
The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.
Belongs to the mitochondrial carrier (TC 2.A.29) family.
研究领域
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Cellular Processes > Cell growth and death > Cellular senescence. (View pathway)
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Human Diseases > Neurodegenerative diseases > Parkinson's disease.
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Human Diseases > Infectious diseases: Viral > Influenza A.
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
限制条款
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