产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3754, RRID:AB_2836118.
展开/折叠
Aldehyde dehydrogenase 3B1; Aldehyde dehydrogenase 7; Aldehyde dehydrogenase family 3 member B1; ALDH4; ALDH7; FLJ26433;
抗原和靶标
- P43353 AL3B1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P43353 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| K41 | Ubiquitination | Uniprot | |
| K89 | Ubiquitination | Uniprot | |
| K148 | Ubiquitination | Uniprot | |
| Y183 | Phosphorylation | Uniprot | |
| T187 | Phosphorylation | Uniprot | |
| S189 | Phosphorylation | Uniprot | |
| K194 | Ubiquitination | Uniprot | |
| K202 | Ubiquitination | Uniprot | |
| T205 | Phosphorylation | Uniprot | |
| T208 | Phosphorylation | Uniprot | |
| K214 | Ubiquitination | Uniprot | |
| K289 | Ubiquitination | Uniprot | |
| K360 | Ubiquitination | Uniprot | |
| S368 | Phosphorylation | Uniprot | |
| K375 | Ubiquitination | Uniprot | |
| K437 | Ubiquitination | Uniprot | |
| S464 | Phosphorylation | Uniprot |
研究背景
Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. Can use both NADP(+) and NAD(+) as electron acceptor. May have a protective role against the cytotoxicity induced by lipid peroxidation.
Dually lipidated in the C-terminus; prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates.
Cell membrane>Lipid-anchor.
Note: Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.
Highest expression in kidney and lung.
Belongs to the aldehyde dehydrogenase family.
研究领域
· Human Diseases > Cancers: Overview > Chemical carcinogenesis.
· Metabolism > Carbohydrate metabolism > Glycolysis / Gluconeogenesis.
· Metabolism > Amino acid metabolism > Histidine metabolism.
· Metabolism > Amino acid metabolism > Tyrosine metabolism.
· Metabolism > Amino acid metabolism > Phenylalanine metabolism.
· Metabolism > Metabolism of other amino acids > beta-Alanine metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - cytochrome P450.
· Metabolism > Global and overview maps > Metabolic pathways.
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