(1)
(6)
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3755, RRID:AB_2836119.
展开/折叠
Acetaldehyde dehydrogenase 5; AL1B1_HUMAN; Aldehyde dehydrogenase 1 family, member B1; Aldehyde dehydrogenase 1B1; Aldehyde dehydrogenase 5; Aldehyde dehydrogenase family 1 member B1; Aldehyde dehydrogenase X; Aldehyde dehydrogenase X mitochondrial; ALDH class 2; Aldh1b1; ALDH5; ALDHX; MGC2230; Mitochondrial aldehyde dehydrogenase X; mitochondrial; OTTHUMP00000021399;
抗原和靶标
- P30837 AL1B1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNLLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P30837 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S11 | Phosphorylation | Uniprot | |
| S21 | Phosphorylation | Uniprot | |
| S27 | Phosphorylation | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| R73 | Methylation | Uniprot | |
| Y135 | Phosphorylation | Uniprot | |
| S217 | Phosphorylation | Uniprot | |
| T283 | Phosphorylation | Uniprot | |
| S330 | Phosphorylation | Uniprot | |
| Y332 | Phosphorylation | Uniprot | |
| K347 | Ubiquitination | Uniprot | |
| K364 | Acetylation | Uniprot | |
| K364 | Ubiquitination | Uniprot | |
| Y373 | Phosphorylation | Uniprot | |
| K379 | Acetylation | Uniprot | |
| K383 | Ubiquitination | Uniprot | |
| K399 | Acetylation | Uniprot | |
| T401 | Phosphorylation | Uniprot | |
| K426 | Ubiquitination | Uniprot | |
| K500 | Ubiquitination | Uniprot |
研究背景
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
Mitochondrion matrix.
Liver, testis and to a lesser extent in brain.
Homotetramer.
Belongs to the aldehyde dehydrogenase family.
研究领域
· Metabolism > Carbohydrate metabolism > Glycolysis / Gluconeogenesis.
· Metabolism > Carbohydrate metabolism > Ascorbate and aldarate metabolism.
· Metabolism > Lipid metabolism > Fatty acid degradation.
· Metabolism > Amino acid metabolism > Valine, leucine and isoleucine degradation.
· Metabolism > Amino acid metabolism > Lysine degradation.
· Metabolism > Amino acid metabolism > Arginine and proline metabolism.
· Metabolism > Amino acid metabolism > Histidine metabolism.
· Metabolism > Amino acid metabolism > Tryptophan metabolism.
· Metabolism > Metabolism of other amino acids > beta-Alanine metabolism.
· Metabolism > Lipid metabolism > Glycerolipid metabolism.
· Metabolism > Carbohydrate metabolism > Pyruvate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
文献引用
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