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| 产品: | AKR1B1 抗体 |
| 货号: | DF3759 |
| 描述: | Rabbit polyclonal antibody to AKR1B1 |
| 应用: | WB IF/ICC |
| 反应: | Human, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 36 KD; 36kD(Calculated). |
| 蛋白号: | P15121 |
| RRID: | AB_2836123 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3759, RRID:AB_2836123.
展开/折叠
ADR; AKR1B 1; Akr1b1; Aldehyde reductase 1; Aldehyde reductase; Aldo keto reductase family 1, member B1; Aldo-keto reductase family 1 member B1; aldo-keto reductase family 1, member B1 (aldose reductase); Aldose reductase; aldr 1; ALDR_HUMAN; aldr1; ALR2; AR; Lii5 2 CTCL tumor antigen; Low Km aldose reductase; MGC1804;
抗原和靶标
Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.
- P15121 ALDR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P15121 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S3 | Phosphorylation | Uniprot | |
| K12 | Acetylation | Uniprot | |
| K12 | Ubiquitination | Uniprot | |
| T20 | Phosphorylation | Uniprot | |
| K22 | Ubiquitination | Uniprot | |
| S23 | Phosphorylation | Uniprot | |
| Y40 | Phosphorylation | Uniprot | |
| Y49 | Phosphorylation | Uniprot | |
| K62 | Ubiquitination | Uniprot | |
| K69 | Ubiquitination | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| Y83 | Phosphorylation | Uniprot | |
| K86 | Ubiquitination | Uniprot | |
| K90 | Ubiquitination | Uniprot | |
| K95 | Acetylation | Uniprot | |
| K95 | Ubiquitination | Uniprot | |
| S98 | Phosphorylation | Uniprot | |
| Y104 | Phosphorylation | Uniprot | |
| K117 | Acetylation | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| Y190 | Phosphorylation | Uniprot | |
| T192 | Phosphorylation | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| Y199 | Phosphorylation | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| S215 | Phosphorylation | Uniprot | |
| R218 | Methylation | Uniprot | |
| K222 | Acetylation | Uniprot | |
| K222 | Methylation | Uniprot | |
| K222 | Ubiquitination | Uniprot | |
| R233 | Methylation | Uniprot | |
| K240 | Ubiquitination | Uniprot | |
| K243 | Acetylation | Uniprot | |
| K243 | Ubiquitination | Uniprot | |
| K263 | Acetylation | Uniprot | |
| K263 | Ubiquitination | Uniprot | |
| S264 | Phosphorylation | Uniprot | |
| T266 | Phosphorylation | Uniprot | |
| C299 | S-Nitrosylation | Uniprot | |
| C304 | S-Nitrosylation | Uniprot | |
| K308 | Acetylation | Uniprot | |
| K308 | Ubiquitination | Uniprot |
研究背景
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls).
Cytoplasm.
Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.
Monomer.
Belongs to the aldo/keto reductase family.
研究领域
· Metabolism > Carbohydrate metabolism > Pentose and glucuronate interconversions.
· Metabolism > Carbohydrate metabolism > Fructose and mannose metabolism.
· Metabolism > Carbohydrate metabolism > Galactose metabolism.
· Metabolism > Lipid metabolism > Glycerolipid metabolism.
· Metabolism > Metabolism of cofactors and vitamins > Folate biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
文献引用
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