产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0204, RRID:AB_2833288.
展开/折叠
Antigen LB39 AA; Antigen LB39-AA; Antigen SK29 AA; Antigen SK29-AA; MAR1_HUMAN; MART 1; MART-1; MART1; Melan A; Melan A protein; Melanoma antigen recognized by T cells 1; Melanoma antigen recognized by T-cells 1; MLAN A; MLANA; OTTHUMP00000021036; OTTHUMP00000021037; OTTHUMP00000021038; Protein Melan-A;
抗原和靶标
- Q16655 MAR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPREDAHFIYGYPKKGHGHSYTTAEEAAGIGILTVILGVLLLIGCWYCRRRNGYRALMDKSLHVGTQCALTRRCPQEGFDHRDSKVSLQEKNCEPVVPNAPPAYEKLSAEQSPPPYSP
翻译修饰 - Q16655 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S87 | Phosphorylation | Uniprot | |
| Y104 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| Y116 | Phosphorylation | Uniprot |
研究背景
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
Acylated.
Endoplasmic reticulum membrane>Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus>trans-Golgi network membrane. Melanosome.
Note: Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
Expression is restricted to melanoma and melanocyte cell lines and retina.
Interacts with PMEL. Interacts with GPR143.
限制条款
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