产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3771, RRID:AB_2836135.
展开/折叠
amyloid beta precursor protein (cytoplasmic tail) binding protein 2; Amyloid beta precursor protein-binding protein 2; Amyloid protein binding protein 2; Amyloid protein-binding protein 2; APBP2_HUMAN; APP BP2; APP-BP2; Appbp2; PAT1; Protein interacting with APP tail 1;
抗原和靶标
- Q92624 APBP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAVELEWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSTSPQSTEEVVQSFLISQNVEGPSC
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q92624 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K68 | Methylation | Uniprot | |
| K68 | Ubiquitination | Uniprot | |
| S106 | Phosphorylation | Uniprot | |
| K178 | Ubiquitination | Uniprot | |
| K187 | Ubiquitination | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| K198 | Ubiquitination | Uniprot | |
| T237 | Phosphorylation | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| K264 | Ubiquitination | Uniprot | |
| K283 | Ubiquitination | Uniprot | |
| K349 | Ubiquitination | Uniprot | |
| K379 | Ubiquitination | Uniprot | |
| K396 | Ubiquitination | Uniprot | |
| K418 | Ubiquitination | Uniprot | |
| K419 | Ubiquitination | Uniprot | |
| K430 | Ubiquitination | Uniprot | |
| K446 | Ubiquitination | Uniprot | |
| K454 | Ubiquitination | Uniprot | |
| K504 | Ubiquitination | Uniprot | |
| Y517 | Phosphorylation | Uniprot | |
| K522 | Ubiquitination | Uniprot |
研究背景
May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.
Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.
Nucleus. Cytoplasm>Cytoskeleton. Membrane>Peripheral membrane protein.
Note: Associated with membranes and microtubules.
Binds APP.
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