| 产品: | DHX8 抗体 |
| 货号: | DF3822 |
| 描述: | Rabbit polyclonal antibody to DHX8 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 150 KD; 139kD(Calculated). |
| 蛋白号: | Q14562 |
| RRID: | AB_2836179 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3822, RRID:AB_2836179.
展开/折叠
ATP dependent RNA helicase DHX8; ATP-dependent RNA helicase dhx8; DDX 8; DDX8; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 8 (RNA helicase); DEAD/H (Asp Glu Ala Asp/His) box polypeptide 8; DEAD/H box 8; DEAD/H box polypeptide 8; DEAH (Asp Glu Ala His) box polypeptide 8; DEAH box polypeptide 8; DEAH box protein 8; DHX 8; dhx8; DHX8_HUMAN; HRH 1; HRH1; PRP 22; PRP22; PRP22, S. cerevisiae, homolog of; PRPF 22; PRPF22; RNA helicase HRH 1; RNA helicase HRH1;
抗原和靶标
- Q14562 DHX8_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFPVLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSRDRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDKYGERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEPLYNRYEEPNAWRISRAFRRR
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q14562 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S14 | Phosphorylation | Uniprot | |
| S129 | Phosphorylation | Uniprot | |
| S177 | Phosphorylation | Uniprot | |
| S179 | Phosphorylation | Uniprot | |
| S224 | Phosphorylation | Uniprot | |
| S226 | Phosphorylation | Uniprot | |
| S228 | Phosphorylation | Uniprot | |
| S230 | Phosphorylation | Uniprot | |
| Y241 | Phosphorylation | Uniprot | |
| T263 | Phosphorylation | Uniprot | |
| T273 | Phosphorylation | Uniprot | |
| T327 | Phosphorylation | Uniprot | |
| S334 | Phosphorylation | Uniprot | |
| T358 | Phosphorylation | Uniprot | |
| T362 | Phosphorylation | Uniprot | |
| S377 | Phosphorylation | Uniprot | |
| S385 | Phosphorylation | Uniprot | |
| S395 | Phosphorylation | Uniprot | |
| K399 | Sumoylation | Uniprot | |
| K399 | Ubiquitination | Uniprot | |
| S412 | Phosphorylation | Uniprot | |
| S456 | Phosphorylation | Uniprot | |
| S460 | Phosphorylation | Uniprot | |
| K539 | Methylation | Uniprot | |
| K547 | Ubiquitination | Uniprot | |
| T554 | Phosphorylation | Uniprot | |
| S557 | Phosphorylation | Uniprot | |
| K628 | Ubiquitination | Uniprot | |
| T694 | Phosphorylation | Uniprot | |
| K868 | Ubiquitination | Uniprot | |
| K885 | Ubiquitination | Uniprot | |
| T914 | Phosphorylation | Uniprot | |
| T915 | Phosphorylation | Uniprot | |
| S996 | Phosphorylation | Uniprot | |
| K1090 | Ubiquitination | Uniprot | |
| K1098 | Ubiquitination | Uniprot | |
| K1105 | Ubiquitination | Uniprot | |
| T1126 | Phosphorylation | Uniprot | |
| Y1202 | Phosphorylation | Uniprot | |
| Y1205 | Phosphorylation | Uniprot |
研究背景
Involved in pre-mRNA splicing as component of the spliceosome. Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.
Nucleus.
Identified in the spliceosome C complex. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation.
The RS domain confers a nuclear localization signal, and appears to facilitate the interaction with the spliceosome.
Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily.
研究领域
· Genetic Information Processing > Transcription > Spliceosome.
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