| 产品: | Calcipressin 1 抗体 |
| 货号: | DF3861 |
| 描述: | Rabbit polyclonal antibody to Calcipressin 1 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 22 KD; 28kD(Calculated). |
| 蛋白号: | P53805 |
| RRID: | AB_2836218 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3861, RRID:AB_2836218.
展开/折叠
Adapt 78; Adapt78; Calcipressin 1; Calcipressin-1; Calcium and oxidant inducible mRNA; CSP 1; CSP1; Down syndrome candidate region 1; Down syndrome critical region gene 1; Down syndrome critical region protein 1; DSC 1; DSC1; DSCR 1; DSCR1; MCIP 1; MCIP1; Modulatory calcineurin interacting protein 1; Myocyte enriched calcineurin interacting protein 1; Myocyte-enriched calcineurin-interacting protein 1; Near DSCR proline rich protein; RCAN1; RCAN1_HUMAN; RCN 1; RCN1; Regulator of calcineurin 1;
抗原和靶标
Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.
- P53805 RCAN1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEDGVAGPQLGAAAEAAEAAEARARPGVTLRPFAPLSGAAEADEGGGDWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLCRAKFESLFRTYDKDITFQYFKSFKRVRINFSNPFSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQEKEEEEEMERMRRPKPKIIQTRRPEYTPIHLS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P53805 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K86 | Ubiquitination | Uniprot | |
| Y94 | Phosphorylation | Uniprot | |
| K128 | Ubiquitination | Uniprot | |
| T129 | Phosphorylation | Uniprot | |
| K134 | Ubiquitination | Uniprot | |
| S163 | Phosphorylation | Q99759 (MAP3K3) , P49841 (GSK3B) | Uniprot |
| S167 | Phosphorylation | Q99759 (MAP3K3) , Q13627 (DYRK1A) , P27361 (MAPK3) , P28482 (MAPK1) | Uniprot |
| T179 | Phosphorylation | Uniprot | |
| Y188 | Phosphorylation | Uniprot | |
| K192 | Ubiquitination | Uniprot | |
| T208 | Phosphorylation | Uniprot | |
| S218 | Phosphorylation | Uniprot | |
| T241 | Phosphorylation | Uniprot | |
| T247 | Phosphorylation | Q13627 (DYRK1A) | Uniprot |
研究背景
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity).
Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life.
Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.
Interacts with RAF1. Interacts with PPP3CA and PPP3R1.
Belongs to the RCAN family.
研究领域
· Organismal Systems > Endocrine system > Thyroid hormone signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Oxytocin signaling pathway.
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