产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3872, RRID:AB_2836225.
展开/折叠
5''-cyclic phosphodiesterase 4C; cAMP specific 3' 5' cyclic phosphodiesterase 4C; cAMP-specific 3''; DPDE 1; DPDE1; MGC126222; PDE 21; PDE 4C; PDE21; Pde4c; PDE4C_HUMAN; Phosphodiesterase 4C; Phosphodiesterase 4C cAMP specific; Phosphodiesterase 4C, cAMP specific (phosphodiesterase E1 dunce homolog, Drosophila); Phosphodiesterase E1 dunce homolog; Phosphodiesterase E1 dunce homolog Drosophila; Phosphodiesterase type 4C;
抗原和靶标
- Q08493 PDE4C_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERDLSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q08493 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y47 | Phosphorylation | Uniprot | |
| S48 | Phosphorylation | Uniprot | |
| S114 | Phosphorylation | Uniprot | |
| S119 | Phosphorylation | Uniprot | |
| S124 | Phosphorylation | Uniprot | |
| S126 | Phosphorylation | Uniprot | |
| S131 | Phosphorylation | Uniprot | |
| S136 | Phosphorylation | Uniprot | |
| T164 | Phosphorylation | Uniprot | |
| S234 | Phosphorylation | Uniprot | |
| K238 | Methylation | Uniprot | |
| S291 | Phosphorylation | Uniprot | |
| T306 | Phosphorylation | Uniprot | |
| T499 | Phosphorylation | Uniprot | |
| S502 | Phosphorylation | Uniprot | |
| S641 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| T646 | Phosphorylation | Uniprot |
研究背景
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Cell projection>Cilium.
Expressed in various tissues but not in cells of the immune system.
Part of a complex containing AKAP5, ADCY5, ADCY6 and PKD2.
Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
研究领域
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Human Diseases > Substance dependence > Morphine addiction.
· Metabolism > Nucleotide metabolism > Purine metabolism.
限制条款
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