产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3898, RRID:AB_2836251.
展开/折叠
Carboxypeptidase E; Carboxypeptidase H; Carboxypeptidase H precursor; CarboxypeptidaseE; CarboxypeptidaseH; CBPE_HUMAN; Cobalt stimulated chromaffin granule carboxypeptidase; CPE; Cph 1; CPH; Enkephalin convertase; Entephalin convertase; Insulin granule associated carboxypeptidase; Prohormone processing carboxypeptidase; Prohormone-processing carboxypeptidase;
抗原和靶标
Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas.
- P16870 CBPE_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGRGGSALLALCGALAACGWLLGAEAQEPGAPAAGMRRRRRLQQEDGISFEYHRYPELREALVSVWLQCTAISRIYTVGRSFEGRELLVIELSDNPGVHEPGEPEFKYIGNMHGNEAVGRELLIFLAQYLCNEYQKGNETIVNLIHSTRIHIMPSLNPDGFEKAASQPGELKDWFVGRSNAQGIDLNRNFPDLDRIVYVNEKEGGPNNHLLKNMKKIVDQNTKLAPETKAVIHWIMDIPFVLSANLHGGDLVANYPYDETRSGSAHEYSSSPDDAIFQSLARAYSSFNPAMSDPNRPPCRKNDDDSSFVDGTTNGGAWYSVPGGMQDFNYLSSNCFEITVELSCEKFPPEETLKTYWEDNKNSLISYLEQIHRGVKGFVRDLQGNPIANATISVEGIDHDVTSAKDGDYWRLLIPGNYKLTASAPGYLAITKKVAVPYSPAAGVDFELESFSERKEEEKEELMEWWKMMSETLNF
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P16870 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K164 | Ubiquitination | Uniprot | |
| K173 | Ubiquitination | Uniprot | |
| K203 | Ubiquitination | Uniprot | |
| K224 | Ubiquitination | Uniprot | |
| S364 | Phosphorylation | Uniprot | |
| Y368 | Phosphorylation | Uniprot | |
| T392 | Phosphorylation | Uniprot | |
| S394 | Phosphorylation | Uniprot | |
| T403 | Phosphorylation | Uniprot | |
| S404 | Phosphorylation | Uniprot | |
| K406 | Ubiquitination | Uniprot | |
| T422 | Phosphorylation | Uniprot | |
| Y428 | Phosphorylation | Uniprot | |
| T432 | Phosphorylation | Uniprot | |
| K433 | Methylation | Uniprot | |
| K433 | Ubiquitination | Uniprot |
研究背景
Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.
Cytoplasmic vesicle>Secretory vesicle. Cytoplasmic vesicle>Secretory vesicle membrane>Peripheral membrane protein. Secreted.
Note: Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions.
Nucleus.
Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas.
Interacts with secretogranin III/SCG3 (By similarity). Isoform 2 interacts with HDAC1 and HDAC2.
Belongs to the peptidase M14 family.
研究领域
· Human Diseases > Endocrine and metabolic diseases > Type I diabetes mellitus.
限制条款
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