CEP170 Antibody - #DF3917

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产品: CEP170 抗体
货号: DF3917
描述: Rabbit polyclonal antibody to CEP170
应用: WB IHC IF/ICC
反应: Human, Mouse
预测: Pig, Bovine, Horse, Sheep, Rabbit
分子量: 160 KD; 175kD(Calculated).
蛋白号: Q5SW79
RRID: AB_2836270

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Pig(100%), Bovine(100%), Horse(88%), Sheep(100%), Rabbit(80%)
克隆:
Polyclonal
特异性:
CEP170 Antibody detects endogenous levels of total CEP170.
RRID:
AB_2836270
引用格式: Affinity Biosciences Cat# DF3917, RRID:AB_2836270.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

XRCC5 binding protein; 4933426L22Rik; A330004A13Rik; AI195353; Centrosomal protein 170kDa; Cep170; FAM68A; KAB; KARP 1 binding protein; KARP1 binding protein; KIAA0470;

抗原和靶标

免疫原:
Uniprot:

Q5SW79(CE170_HUMAN) >>Visit HPA database.

基因/基因ID:
CEP170(9859)
序列:
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFGYDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQPSWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSSHITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSDVPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVTSSAHHRGGHGVPHGKLLKQKSEEPSVSIPFLQTALLRSSGSLGHRPSQEMDKMLKNQATSATSEKDNDDDQSDKGTYTIELENPNSEEVEARKMIDKVFGVDDNQDYNRPVINEKHKDLIKDWALSSAAAVMEERKPLTTSGFHHSEEGTSSSGSKRWVSQWASLAANHTRHDQEERIMEFSAPLPLENETEISESGMTVRSTGSATSLASQGERRRRTLPQLPNEEKSLESHRAKVVTQRSEIGEKQDTELQEKETPTQVYQKDKQDADRPLSKMNRAVNGETLKTGGDNKTLLHLGSSAPGKEKSETDKETSLVKQTLAKLQQQEQREEAQWTPTKLSSKNVSGQTDKCREETFKQESQPPEKNSGHSTSKGDRVAQSESKRRKAEEILKSQTPKGGDKKESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSSLALTSASRIRERSESLDPDSSMDTTLILKDTEAVMAFLEAKLREDNKTDEGPDTPSYNRDNSISPESDVDTASTISLVTGETERKSTQKRKSFTSLYKDRCSTGSPSKDVTKSSSSGAREKMEKKTKSRSTDVGSRADGRKFVQSSGRIRQPSVDLTDDDQTSSVPHSAISDIMSSDQETYSCKPHGRTPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPRPTRTSLLRRARLGEASDSELADADKASVASEVSTTSSTSKPPTGRRNISRIDLLAQPRRTRLGSLSARSDSEATISRSSASSRTAEAIIRSGARLVPSDKFSPRIRANSISRLSDSKVKSMTSAHGSASVNSRWRRFPTDYASTSEDEFGSNRNSPKHTRLRTSPALKTTRLQSAGSAMPTSSSFKHRIKEQEDYIRDWTAHREEIARISQDLALIAREINDVAGEIDSVTSSGTAPSTTVSTAATTPGSAIDTREELVDRVFDESLNFRKIPPLVHSKTPEGNNGRSGDPRPQAAEPPDHLTITRRRTWSRDEVMGDNLLLSSVFQFSKKIRQSIDKTAGKIRILFKDKDRNWDDIESKLRAESEVPIVKTSSMEISSILQELKRVEKQLQAINAMIDPDGTLEALNNMGFPSAMLPSPPKQKSSPVNNHHSPGQTPTLGQPEARALHPAAVSAAAEFENAESEADFSIHFNRFNPDGEEEDVTVQE

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Horse
88
Rabbit
80
Dog
75
Chicken
57
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q5SW79 作为底物

Site PTM Type Enzyme
T4 Phosphorylation
S5 Phosphorylation
S10 Phosphorylation
K41 Ubiquitination
K58 Ubiquitination
S62 Phosphorylation
R72 Methylation
Y78 Phosphorylation
K111 Ubiquitination
S122 Phosphorylation
S125 Phosphorylation
S126 Phosphorylation
S133 Phosphorylation
K137 Ubiquitination
S138 Phosphorylation
S141 Phosphorylation
K142 Ubiquitination
K163 Ubiquitination
T174 Phosphorylation
Y177 Phosphorylation
S181 Phosphorylation
K191 Ubiquitination
C212 S-Nitrosylation
S223 Phosphorylation
S239 Phosphorylation
Y240 Phosphorylation
K246 Ubiquitination
S252 Phosphorylation
K300 Methylation
S309 Phosphorylation
S312 Phosphorylation
S313 Phosphorylation
T316 Phosphorylation
S354 Phosphorylation
S356 Phosphorylation
S359 Phosphorylation
Y364 Phosphorylation
K366 Ubiquitination
T377 Phosphorylation
S379 Phosphorylation
S381 Phosphorylation
S391 Phosphorylation
T395 Phosphorylation
K409 Ubiquitination
R431 Methylation
K440 Methylation
S446 Phosphorylation
S450 Phosphorylation
S452 Phosphorylation
S463 Phosphorylation
S464 Phosphorylation
S466 Phosphorylation
S472 Phosphorylation
T484 Phosphorylation
S497 Phosphorylation
T501 Phosphorylation
Y502 Phosphorylation
T503 Phosphorylation
K522 Ubiquitination
Y532 Phosphorylation
K561 Ubiquitination
T565 Phosphorylation P28482 (MAPK1)
S566 Phosphorylation
S571 Phosphorylation
T575 Phosphorylation
S578 Phosphorylation
S580 Phosphorylation
T616 Phosphorylation
S619 Phosphorylation
S627 Phosphorylation
T628 Phosphorylation
S630 Phosphorylation
T632 Phosphorylation
S633 Phosphorylation
S636 Phosphorylation
T644 Phosphorylation
S654 Phosphorylation
T664 Phosphorylation
S667 Phosphorylation
T675 Phosphorylation
T682 Phosphorylation
T712 Phosphorylation
T718 Phosphorylation
S724 Phosphorylation
S725 Phosphorylation
S732 Phosphorylation
T734 Phosphorylation
S739 Phosphorylation
K742 Ubiquitination
K747 Ubiquitination
T760 Phosphorylation
S785 Phosphorylation
T820 Phosphorylation
S832 Phosphorylation
S838 Phosphorylation
T840 Phosphorylation
S845 Phosphorylation
S861 Phosphorylation
S862 Phosphorylation
T863 Phosphorylation
S871 Phosphorylation
S879 Phosphorylation
S881 Phosphorylation
S886 Phosphorylation
S887 Phosphorylation
T890 Phosphorylation
T914 Phosphorylation
T920 Phosphorylation
S922 Phosphorylation
Y923 Phosphorylation
S928 Phosphorylation
S930 Phosphorylation
S933 Phosphorylation
T937 Phosphorylation
S939 Phosphorylation
S958 Phosphorylation
T960 Phosphorylation
S961 Phosphorylation
S971 Phosphorylation
S980 Phosphorylation
S1011 Phosphorylation
S1012 Phosphorylation
S1019 Phosphorylation
T1023 Phosphorylation
T1028 Phosphorylation
S1029 Phosphorylation
S1034 Phosphorylation
S1037 Phosphorylation
S1041 Phosphorylation
S1042 Phosphorylation
T1046 Phosphorylation
Y1047 Phosphorylation
S1048 Phosphorylation
T1055 Phosphorylation
T1058 Phosphorylation
S1059 Phosphorylation
T1078 Phosphorylation
S1079 Phosphorylation
S1083 Phosphorylation
S1085 Phosphorylation
S1086 Phosphorylation
T1091 Phosphorylation
S1112 Phosphorylation
S1114 Phosphorylation
S1129 Phosphorylation
S1132 Phosphorylation
S1133 Phosphorylation
S1145 Phosphorylation
T1156 Phosphorylation
S1160 Phosphorylation
S1162 Phosphorylation
S1165 Phosphorylation
S1167 Phosphorylation
T1170 Phosphorylation
T1180 Phosphorylation
S1194 Phosphorylation
S1198 Phosphorylation
S1205 Phosphorylation
S1207 Phosphorylation
S1210 Phosphorylation
S1212 Phosphorylation
K1215 Methylation
S1216 Phosphorylation
S1223 Phosphorylation
S1225 Phosphorylation
T1235 Phosphorylation
Y1237 Phosphorylation
S1239 Phosphorylation
T1240 Phosphorylation
S1241 Phosphorylation
S1247 Phosphorylation
S1251 Phosphorylation
T1259 Phosphorylation
S1260 Phosphorylation
T1265 Phosphorylation
S1270 Phosphorylation
S1273 Phosphorylation
S1279 Phosphorylation
S1280 Phosphorylation
K1282 Methylation
Y1291 Phosphorylation
S1306 Phosphorylation
S1362 Phosphorylation
K1367 Ubiquitination
S1374 Phosphorylation
T1376 Phosphorylation
S1384 Phosphorylation
T1399 Phosphorylation
T1405 Phosphorylation
S1407 Phosphorylation
S1431 Phosphorylation
K1456 Ubiquitination
S1461 Phosphorylation
K1481 Ubiquitination
S1515 Phosphorylation
S1521 Phosphorylation
S1522 Phosphorylation
S1529 Phosphorylation
T1533 Phosphorylation
S1560 Phosphorylation

研究背景

功能:

Plays a role in microtubule organization. Required for centriole subdistal appendage assembly.

翻译修饰:

Phosphorylated; probably by PLK1.

细胞定位:

Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome>Centriole. Cytoplasm>Cytoskeleton>Spindle.
Note: Associated with the mature mother centriole. Associated with spindle microtubules during mitosis. Localizes to the distal appendage region of the centriole.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Interacts with CCDC68 and CCDC120; leading to recruitment to centrosomes. Interacts with PLK1. Interacts with NIN (By similarity). Interacts with FHDC1 (By similarity).

蛋白家族:

Belongs to the CEP170 family.

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