产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3919, RRID:AB_2836272.
展开/折叠
Centrosomal protein 57kDa; Centrosomal protein of 57 kDa; Cep57; Cep57 protein; CEP57_HUMAN; FGF2 interacting protein; FGF2-interacting protein; KIAA0092; MVA2; PIG8; Proliferation inducing protein 8; Testis specific protein 57; Testis-specific protein 57; Translokin; TSP57;
抗原和靶标
- Q86XR8 CEP57_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAASVSAASGSHLSNSFAEPSRSNGSMVRHSSSPYVVYPSDKPFLNSDLRRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQSIQNSLQSSSLCWDY
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q86XR8 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S10 | Phosphorylation | Uniprot | |
| S15 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| S33 | Phosphorylation | Uniprot | |
| S34 | Phosphorylation | Uniprot | |
| Y36 | Phosphorylation | Uniprot | |
| K43 | Ubiquitination | Uniprot | |
| S53 | Phosphorylation | Uniprot | |
| S55 | Phosphorylation | Uniprot | |
| K56 | Ubiquitination | Uniprot | |
| T58 | Phosphorylation | Uniprot | |
| Y61 | Phosphorylation | Uniprot | |
| S64 | Phosphorylation | Uniprot | |
| S66 | Phosphorylation | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| K95 | Ubiquitination | Uniprot | |
| T96 | Phosphorylation | Uniprot | |
| T101 | Phosphorylation | Uniprot | |
| Y104 | Phosphorylation | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| K106 | Ubiquitination | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| K119 | Ubiquitination | Uniprot | |
| K124 | Ubiquitination | Uniprot | |
| K139 | Ubiquitination | Uniprot | |
| K145 | Ubiquitination | Uniprot | |
| K155 | Ubiquitination | Uniprot | |
| K167 | Ubiquitination | Uniprot | |
| K188 | Ubiquitination | Uniprot | |
| K198 | Ubiquitination | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| K209 | Ubiquitination | Uniprot | |
| K225 | Ubiquitination | Uniprot | |
| K230 | Ubiquitination | Uniprot | |
| K248 | Ubiquitination | Uniprot | |
| T250 | Phosphorylation | Uniprot | |
| K265 | Acetylation | Uniprot | |
| K265 | Sumoylation | Uniprot | |
| K269 | Acetylation | Uniprot | |
| K319 | Ubiquitination | Uniprot | |
| K334 | Ubiquitination | Uniprot | |
| S388 | Phosphorylation | Uniprot | |
| T390 | Phosphorylation | Uniprot | |
| K394 | Ubiquitination | Uniprot | |
| K396 | Ubiquitination | Uniprot | |
| K411 | Ubiquitination | Uniprot | |
| K417 | Ubiquitination | Uniprot | |
| K420 | Ubiquitination | Uniprot | |
| K462 | Ubiquitination | Uniprot | |
| K473 | Acetylation | Uniprot | |
| K476 | Ubiquitination | Uniprot |
研究背景
Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1.
Nucleus. Cytoplasm. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome.
Ubiquitous.
Homodimer and homooligomer. Interacts with microtubules. Interacts with FGF2 and RAP80. Does not interact with FGF1 or FGF2 isoform 24 kDa.
The C-terminal region mediates the interaction with microtubules and is able to nucleate and bundles microtubules in vitro.
The centrosome localization domain (CLD) region mediates the localization to centrosomes and homooligomerization.
Belongs to the translokin family.
限制条款
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