| 产品: | CNGA1 抗体 |
| 货号: | DF3929 |
| 描述: | Rabbit polyclonal antibody to CNGA1 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 79 KD; 80kD(Calculated). |
| 蛋白号: | P29973 |
| RRID: | AB_2836282 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3929, RRID:AB_2836282.
展开/折叠
cGMP gated cation channel alpha 1; cGMP-gated cation channel alpha-1; CNCG; CNCG1; CNG 1; CNG channel alpha 1; CNG channel alpha-1; CNG-1; CNG1; Cnga1; CNGA1_HUMAN; Cyclic nucleotide gated cation channel 1; Cyclic nucleotide gated channel alpha 1; Cyclic nucleotide gated channel photoreceptor; Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; Cyclic nucleotide-gated channel; Interleukin 1 homologue; OTTHUMP00000218675; OTTHUMP00000223313; OTTHUMP00000223314; photoreceptor; RCNC1; RCNCa; RCNCalpha; Rod photoreceptor cGMP gated channel subunit alpha; Rod photoreceptor cGMP-gated channel subunit alpha; RP49;
抗原和靶标
- P29973 CNGA1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIDTEFSSIEGPGAESGPIDST
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P29973 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S15 | Phosphorylation | Uniprot | |
| T18 | Phosphorylation | Uniprot | |
| K143 | Acetylation | Uniprot | |
| K145 | Acetylation | Uniprot | |
| K147 | Acetylation | Uniprot | |
| K152 | Acetylation | Uniprot | |
| Y223 | Phosphorylation | Uniprot | |
| Y349 | Phosphorylation | Uniprot | |
| Y351 | Phosphorylation | Uniprot | |
| Y354 | Phosphorylation | Uniprot | |
| T473 | Phosphorylation | Uniprot | |
| K556 | Methylation | Uniprot | |
| K566 | Methylation | Uniprot |
研究背景
Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.
Cell membrane>Multi-pass membrane protein.
Rod cells in the retina.
Forms a heterotetramer with CNGB1 in a 3:1 ratio. May also form cyclic nucleotide-activated homotetrameric channels, that are efficiently activated by saturating cGMP, but poorly activated by saturating cAMP compared to the heterotetramer with CNGB1.
The C-terminal coiled-coil domain mediates homotrimerization of CNGA subunits.
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily.
研究领域
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Organismal Systems > Sensory system > Phototransduction.
限制条款
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