产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3988, RRID:AB_2836348.
展开/折叠
ARVC 10; ARVC10; ARVD 10; ARVD10; Cadherin family member 5; CDHF 5; CDHF5; CMD1BB; Desmoglein 2; Desmoglein-2; Desmoglein2; DSG 2; DSG2; DSG2_HUMAN; HDGC; HDGC included; Human Desmoglein colon; MGC117034; MGC117036; MGC117037;
抗原和靶标
- Q14126 DSG2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MARSPGRAYALLLLLICFNVGSGLHLQVLSTRNENKLLPKHPHLVRQKRAWITAPVALREGEDLSKKNPIAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGYALDARGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDADEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGEVTDKPVKQAQVQIRILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPGMAEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVGLGPAAIALMILAFLLLLLVPLLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGRWEEHRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVYSQEETESLNASIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATETSMNTASHSLCEQTMVNSENTYSSGSSFPVPKSLQEANAEKVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVYAPASTLVDQPYANEGTVVVTERVIQPHGGGSNPLEGTQHLQDVPYVMVRERESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTENSMTARNTTVSGAGVPGPLPDFGLEESGHSNSTITTSSTRVTKHSTVQHSYS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q14126 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S4 | Phosphorylation | Uniprot | |
| S75 | Phosphorylation | Uniprot | |
| R81 | Methylation | Uniprot | |
| N112 | N-Glycosylation | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| N182 | N-Glycosylation | Uniprot | |
| Y207 | Phosphorylation | Uniprot | |
| Y212 | Phosphorylation | Uniprot | |
| Y221 | Phosphorylation | Uniprot | |
| Y235 | Phosphorylation | Uniprot | |
| T291 | Phosphorylation | Uniprot | |
| S363 | Phosphorylation | Uniprot | |
| R434 | Methylation | Uniprot | |
| N462 | N-Glycosylation | Uniprot | |
| T484 | Phosphorylation | Uniprot | |
| S551 | Phosphorylation | Uniprot | |
| T552 | Phosphorylation | Uniprot | |
| S559 | Phosphorylation | Uniprot | |
| K561 | Ubiquitination | Uniprot | |
| T645 | Phosphorylation | Uniprot | |
| T650 | Phosphorylation | Uniprot | |
| K667 | Ubiquitination | Uniprot | |
| S680 | Phosphorylation | Uniprot | |
| T695 | Phosphorylation | Uniprot | |
| K697 | Methylation | Uniprot | |
| K697 | Ubiquitination | Uniprot | |
| S699 | Phosphorylation | Uniprot | |
| S700 | Phosphorylation | Uniprot | |
| S701 | Phosphorylation | Uniprot | |
| S703 | Phosphorylation | Uniprot | |
| K706 | Ubiquitination | Uniprot | |
| S712 | Phosphorylation | Uniprot | |
| S723 | Phosphorylation | Uniprot | |
| S726 | Phosphorylation | Uniprot | |
| T733 | Phosphorylation | Uniprot | |
| T744 | Phosphorylation | Uniprot | |
| T745 | Phosphorylation | Uniprot | |
| K746 | Ubiquitination | Uniprot | |
| R773 | Methylation | Uniprot | |
| Y775 | Phosphorylation | Uniprot | |
| K779 | Ubiquitination | Uniprot | |
| S782 | Phosphorylation | Uniprot | |
| Y783 | Phosphorylation | Uniprot | |
| T791 | Phosphorylation | Uniprot | |
| T804 | Phosphorylation | Uniprot | |
| S806 | Phosphorylation | Uniprot | |
| S810 | Phosphorylation | Uniprot | |
| S815 | Phosphorylation | Uniprot | |
| K832 | Ubiquitination | Uniprot | |
| T835 | Phosphorylation | Uniprot | |
| K849 | Ubiquitination | Uniprot | |
| T874 | Phosphorylation | Uniprot | |
| T881 | Phosphorylation | Uniprot | |
| Y882 | Phosphorylation | Uniprot | |
| S884 | Phosphorylation | Uniprot | |
| S893 | Phosphorylation | Uniprot | |
| K901 | Ubiquitination | Uniprot | |
| T903 | Phosphorylation | Uniprot | |
| S911 | Phosphorylation | Uniprot | |
| T922 | Phosphorylation | Uniprot | |
| S939 | Phosphorylation | Uniprot | |
| T942 | Phosphorylation | Uniprot | |
| Y968 | Phosphorylation | Uniprot | |
| T973 | Phosphorylation | Uniprot | |
| Y979 | Phosphorylation | Uniprot | |
| T984 | Phosphorylation | Uniprot | |
| S999 | Phosphorylation | Uniprot | |
| Y1013 | Phosphorylation | Uniprot | |
| S1021 | Phosphorylation | Uniprot | |
| S1055 | Phosphorylation | Uniprot | |
| T1056 | Phosphorylation | Uniprot | |
| S1059 | Phosphorylation | Uniprot | |
| S1060 | Phosphorylation | Uniprot | |
| Y1061 | Phosphorylation | Uniprot | |
| S1093 | Phosphorylation | Uniprot | |
| S1098 | Phosphorylation | Uniprot | |
| T1099 | Phosphorylation | Uniprot | |
| K1109 | Ubiquitination | Uniprot | |
| S1111 | Phosphorylation | Uniprot | |
| Y1117 | Phosphorylation | Uniprot | |
| S1118 | Phosphorylation | Uniprot |
研究背景
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Cell membrane>Single-pass type I membrane protein. Cell junction>Desmosome.
All of the tissues tested and carcinomas.
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
研究领域
· Human Diseases > Cardiovascular diseases > Arrhythmogenic right ventricular cardiomyopathy (ARVC).
限制条款
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