| 产品: | CCNB1IP1 抗体 |
| 货号: | DF4016 |
| 描述: | Rabbit polyclonal antibody to CCNB1IP1 |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Pig, Bovine, Horse, Sheep, Dog |
| 分子量: | 32 KD; 32kD(Calculated). |
| 蛋白号: | Q9NPC3 |
| RRID: | AB_2836376 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4016, RRID:AB_2836376.
展开/折叠
C14orf18; CCNB1IP1; Chromosome 14 open reading frame 18; CIP1_HUMAN; Cyclin B1 interacting protein 1; cyclin B1 interacting protein 1, E3 ubiquitin protein ligase; Cyclin-B1-interacting protein 1; E3 ubiquitin-protein ligase CCNB1IP1; Enhancer of invasion 10; Gm288; HEI10; Human enhancer of invasion 10; mei4;
抗原和靶标
Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.
- Q9NPC3 CIP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLCEDMLLCNYRKCRIKLSGYAWVTACSHIFCDQHGSGEFSRSPAICPACNSTLSGKLDIVRTELSPSEEYKAMVLAGLRPEIVLDISSRALAFWTYQVHQERLYQEYNFSKAEGHLKQMEKIYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNNSKFPLDNTPVRNRGDGDGDFQFRPFFAGSPTAPEPSNSFFSFVSPSRELEQQQVSSRAFKVKRI
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9NPC3 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y125 | Phosphorylation | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| K154 | Ubiquitination | Uniprot | |
| S158 | Phosphorylation | Uniprot | |
| S161 | Phosphorylation | Uniprot | |
| Y178 | Phosphorylation | Uniprot | |
| S180 | Phosphorylation | Uniprot | |
| T221 | Phosphorylation | Uniprot | |
| S257 | Phosphorylation | Uniprot | |
| S259 | Phosphorylation | Uniprot |
研究背景
Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
Ubiquitinated; autoubiquitinated.
Phosphorylated by CDK1 on serine or threonine residues (in vitro).
Nucleus. Chromosome.
Note: Associates to the synaptonemal complex.
Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.
Interacts with CCNB1, UBE2L3 and NF2.
限制条款
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