| 产品: | GGH 抗体 |
| 货号: | DF4073 |
| 描述: | Rabbit polyclonal antibody to GGH |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 预测: | Zebrafish, Bovine, Horse, Sheep, Dog, Xenopus |
| 分子量: | 36 KD; 36kD(Calculated). |
| 蛋白号: | Q92820 |
| RRID: | AB_2836447 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4073, RRID:AB_2836447.
展开/折叠
Conjugase; folylpolygammaglutamyl hydrolase; gamma glutamyl hydrolase; Gamma-Glu-X carboxypeptidase; Gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); Gamma-glutamyl hydrolase; GGH; GGH_HUMAN; gH;
抗原和靶标
- Q92820 GGH_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASYVKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSDYAKVAKIFYNLSIQSFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTELLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKIEFISTMEGYKYPVYGVQWHPEKAPYEWKNLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEEKALIYQFSPIYTGNISSFQQCYIFD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q92820 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K81 | Ubiquitination | Uniprot | |
| K109 | Ubiquitination | Uniprot | |
| N163 | N-Glycosylation | Uniprot | |
| N203 | N-Glycosylation | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| N307 | N-Glycosylation | Uniprot |
研究背景
Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
Secreted>Extracellular space. Lysosome. Melanosome.
Note: While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Homodimer.
Belongs to the peptidase C26 family.
研究领域
· Human Diseases > Drug resistance: Antineoplastic > Antifolate resistance.
· Metabolism > Metabolism of cofactors and vitamins > Folate biosynthesis.
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