GDF15 Antibody - #DF4096

Fig. 8. QZC significantly reduces HCT116 xenograft tumor growth in nude mice. Mice were divided into model, QZCL (1.5 g/kg), QZCH (4.5 g/kg), QZCL/5-FU (1.5 g/kg+5-FU), and 5-FU groups (n = 12 mice/group). (A) Rate of tumor formation. (B) Xenograft tumor volumes (mm3 ) in nude mice. (C) Average final tumor weight. (D) Images of all tumors from all five groups. (E) Body weight change in nude mice. (F) Expression of the PARP, FoxO3a, AMPK and MAPK/ERK proteins in xenograft tumors, as determined using Western blot analyses. (G–I) The expression levels of NAG-1 in tumors and serum from nude mice, as determined using Western blotting (G), qRT-PCR (H), and ELISA (I). The relative intensities of all proteins were calculated after normalization to the total protein or β-actin. Data are presented as the means ± SE. *p < 0.05, **p < 0.01, and ***p < 0.001 compared with the model group; ##p < 0.05 for the comparison between the QZCH and model groups; △△p < 0.01 for the comparison between the 5-FU and model groups; and ◆◆p < 0.01 for the comparison between the QZCL/5-FU and model groups.