(2)
(3)
| 产品: | KCNN4 抗体 |
| 货号: | DF4132 |
| 描述: | Rabbit polyclonal antibody to KCNN4 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Horse, Sheep, Rabbit, Dog |
| 分子量: | 48 KD; 48kD(Calculated). |
| 蛋白号: | O15554 |
| RRID: | AB_2836497 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4132, RRID:AB_2836497.
展开/折叠
DHS2; hIKCa1; hKCa4; hSK4; IK; IK1; IKCa1; Intermediate conductance calcium activated potassium channel protein 4; Intermediate conductance calcium-activated potassium channel protein 4; KCa3.1; KCa4; KCNN 4; Kcnn4; KCNN4_HUMAN; Potassium calcium activated channel subfamily N member 4; Potassium intermediate/small conductance calcium activated channel, subfamily N, member 4; Putative Gardos channel; SK4; SKCa 4; SKCa4;
抗原和靶标
- O15554 KCNN4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O15554 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S178 | Phosphorylation | Uniprot | |
| Y199 | Phosphorylation | Uniprot | |
| S314 | Phosphorylation | Uniprot | |
| T329 | Phosphorylation | Uniprot | |
| S334 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| H358 | Phosphorylation | P22392 (NME2) | Uniprot |
| S367 | Phosphorylation | Uniprot | |
| K394 | Ubiquitination | Uniprot | |
| T398 | Phosphorylation | Uniprot |
研究背景
Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. Plays a role in the late stages of EGF-induced macropinocytosis.
Phosphorylation at His-358 by NDKB activates the channel, and conversely it's dephosphorylation by PHPT1 inhibits the channel.
Cell membrane>Multi-pass membrane protein.
Widely expressed in non-excitable tissues.
Heterotetramer of potassium channel proteins (Probable). Interacts with MTMR6.
Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily.
研究领域
· Organismal Systems > Endocrine system > Insulin secretion. (View pathway)
· Organismal Systems > Digestive system > Salivary secretion.
· Organismal Systems > Digestive system > Protein digestion and absorption.
文献引用
Application: WB Species: Human Sample: kidney renal clear cell
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