| 产品: | MASP2 抗体 |
| 货号: | DF4151 |
| 描述: | Rabbit polyclonal antibody to MASP2 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 分子量: | 75 KD; 76kD(Calculated). |
| 蛋白号: | O00187 |
| RRID: | AB_2836516 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4151, RRID:AB_2836516.
展开/折叠
Mannan binding lectin serine peptidase 2; Mannan binding lectin serine protease 2; Mannose binding protein associated serine protease 2; MAP 19; MAP19; MASP 2; MBL associated plasma protein of 19 kD; MBL associated serine protease 2; Small MBL associated protein; sMAP;
抗原和靶标
- O00187 MASP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENIISDF
翻译修饰 - O00187 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T250 | Phosphorylation | Uniprot | |
| T262 | Phosphorylation | Uniprot | |
| Y388 | Phosphorylation | Uniprot | |
| Y394 | Phosphorylation | Uniprot | |
| Y401 | Phosphorylation | Uniprot | |
| T549 | Phosphorylation | Uniprot | |
| Y587 | Phosphorylation | Uniprot | |
| T599 | Phosphorylation | Uniprot | |
| Y602 | Phosphorylation | Uniprot |
研究背景
Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Activated by cleavage after Arg-444. The uncleaved zymogen is inactive towards synthetic substrates, but has sufficient activity to effect autocatalytic cleavage.
Secreted.
Plasma.
Homodimer; disulfide-linked. Binds MBL2. Isoform 2 binds to MASP1. Binds SERPING1. Dimerization and MBL2 binding requires calcium ions.
Belongs to the peptidase S1 family.
研究领域
· Human Diseases > Infectious diseases: Bacterial > Staphylococcus aureus infection.
· Organismal Systems > Immune system > Complement and coagulation cascades. (View pathway)
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