| 产品: | MGST1 抗体 |
| 货号: | DF4161 |
| 描述: | Rabbit polyclonal antibody to MGST1 |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 18 KD; 18kD(Calculated). |
| 蛋白号: | P10620 |
| RRID: | AB_2836526 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4161, RRID:AB_2836526.
展开/折叠
MGST1; Glutathione S transferase 12; GST12; MGST 1; MGST; MGST I; MGST1; MGST1_HUMAN; Microsomal glutathione S-transferase 1; Microsomal GST 1; Microsomal GST-1; Microsomal GST-I;
抗原和靶标
- P10620 MGST1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAKKYLRTDDRVERVRRAHLNDLENIIPFLGIGLLYSLSGPDPSTAILHFRLFVGARIYHTIAYLTPLPQPNRALSFFVGYGVTLSMAYRLLKSKLYL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P10620 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S31 | Phosphorylation | Uniprot | |
| Y37 | Phosphorylation | Uniprot | |
| T40 | Phosphorylation | Uniprot | |
| K42 | Acetylation | Uniprot | |
| C50 | S-Nitrosylation | Uniprot | |
| K55 | Acetylation | Uniprot | |
| K55 | Ubiquitination | Uniprot | |
| K60 | Ubiquitination | Uniprot | |
| Y121 | Phosphorylation | Uniprot | |
| T123 | Phosphorylation | Uniprot |
研究背景
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.
Peroxynitrite induces nitration at Tyr-93 which activates the enzyme.
Microsome. Mitochondrion outer membrane>Peripheral membrane protein. Endoplasmic reticulum membrane>Multi-pass membrane protein.
Highly expressed in liver.
Homotrimer; The trimer binds only one molecule of glutathione.
Belongs to the MAPEG family.
研究领域
· Human Diseases > Drug resistance: Antineoplastic > Platinum drug resistance.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Overview > Chemical carcinogenesis.
· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma. (View pathway)
· Metabolism > Metabolism of other amino acids > Glutathione metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.
限制条款
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