| 产品: | SLC22A5 抗体 |
| 货号: | DF4269 |
| 描述: | Rabbit polyclonal antibody to SLC22A5 |
| 应用: | WB |
| 反应: | Human, Rat |
| 预测: | Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 65 KD; 63kD(Calculated). |
| 蛋白号: | O76082 |
| RRID: | AB_2836620 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4269, RRID:AB_2836620.
展开/折叠
CDSP; High-affinity sodium-dependent carnitine cotransporter; OCTN2; OCTN2VT; Organic cation/carnitine transporter 2; S22A5_HUMAN; Slc22a5; Solute carrier family 22 (organic cation/carnitine transporter) member 5; Solute carrier family 22 member 5;
抗原和靶标
Strongly expressed in kidney, skeletal muscle, heart and placenta. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells.
- O76082 S22A5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O76082 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N57 | N-Glycosylation | Uniprot | |
| T88 | Phosphorylation | Uniprot | |
| N91 | N-Glycosylation | Uniprot | |
| S93 | Phosphorylation | Uniprot | |
| K302 | Ubiquitination | Uniprot | |
| K324 | Ubiquitination | Uniprot | |
| T468 | Phosphorylation | Uniprot | |
| S470 | Phosphorylation | Uniprot | |
| S474 | Phosphorylation | Uniprot | |
| Y486 | Phosphorylation | Uniprot | |
| K543 | Ubiquitination | Uniprot | |
| T550 | Phosphorylation | Uniprot | |
| K553 | Ubiquitination | Uniprot |
研究背景
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Membrane>Multi-pass membrane protein.
Strongly expressed in kidney, skeletal muscle, heart and placenta. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells.
Interacts with PDZK1.
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
研究领域
· Human Diseases > Cancers: Overview > Choline metabolism in cancer. (View pathway)
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