| 产品: | PEX19 抗体 |
| 货号: | DF4281 |
| 描述: | Rabbit polyclonal antibody to PEX19 |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Pig, Bovine, Horse, Dog |
| 分子量: | 33 KD; 33kD(Calculated). |
| 蛋白号: | P40855 |
| RRID: | AB_2836632 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4281, RRID:AB_2836632.
展开/折叠
33 kDa housekeeping protein; D1S2223E; HK33; Housekeeping gene 33kD; OK/SW-cl.22; PBD12A; Peroxin 19; Peroxin-19; Peroxisomal biogenesis factor 19; Peroxisomal farnesylated protein; PEX19; PEX19_HUMAN; PMP1; PMPI; PXF; PXMP1;
抗原和靶标
Ubiquitously expressed. Isoform 1 is strongly predominant in all tissues except in utero where isoform 2 is the main form.
- P40855 PEX19_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAAEEGCSVGAEADRELEELLESALDDFDKAKPSPAPPSTTTAPDASGPQKRSPGDTAKDALFASQEKFFQELFDSELASQATAEFEKAMKELAEEEPHLVEQFQKLSEAAGRVGSDMTSQQEFTSCLKETLSGLAKNATDLQNSSMSEEELTKAMEGLGMDEGDGEGNILPIMQSIMQNLLSKDVLYPSLKEITEKYPEWLQSHRESLPPEQFEKYQEQHSVMCKICEQFEAETPTDSETTQKARFEMVLDLMQQLQDLGHPPKELAGEMPPGLNFDLDALNLSGPPGASGEQCLIM
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P40855 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| S35 | Phosphorylation | Uniprot | |
| S40 | Phosphorylation | Uniprot | |
| T42 | Phosphorylation | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| S54 | Phosphorylation | Uniprot | |
| T58 | Phosphorylation | Uniprot | |
| K60 | Ubiquitination | Uniprot | |
| S66 | Phosphorylation | Uniprot | |
| K69 | Ubiquitination | Uniprot | |
| K89 | Ubiquitination | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| S117 | Phosphorylation | Uniprot | |
| K130 | Ubiquitination | Uniprot | |
| S134 | Phosphorylation | Uniprot | |
| K138 | Ubiquitination | Uniprot | |
| T141 | Phosphorylation | Uniprot | |
| S146 | Phosphorylation | Uniprot | |
| S147 | Phosphorylation | Uniprot | |
| S149 | Phosphorylation | Uniprot | |
| S177 | Phosphorylation | Uniprot | |
| S184 | Phosphorylation | Uniprot | |
| K193 | Ubiquitination | Uniprot | |
| K198 | Ubiquitination | Uniprot | |
| Y199 | Phosphorylation | Uniprot | |
| T236 | Phosphorylation | Uniprot | |
| K245 | Ubiquitination | Uniprot |
研究背景
Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
Cytoplasm. Peroxisome membrane>Lipid-anchor>Cytoplasmic side.
Note: Mainly cytoplasmic. Some fraction membrane-associated to the outer surface of peroxisomes.
Ubiquitously expressed. Isoform 1 is strongly predominant in all tissues except in utero where isoform 2 is the main form.
Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
Belongs to the peroxin-19 family.
研究领域
· Cellular Processes > Transport and catabolism > Peroxisome. (View pathway)
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