产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4299, RRID:AB_2836650.
展开/折叠
C1 esterase inhibitor; C1 Inh; C1 inhibiting factor; C1 inhibitor; C1-inhibiting factor; C1IN; C1Inh; C1NH; complement component 1 inhibitor; esterase inhibitor; HAE1; HAE2; IC1_HUMAN; Plasma protease C1 inhibitor; Serine (or cysteine) proteinase inhibitor clade G member 1; serine/cysteine proteinase inhibitor clade G member 1; Serpin G1; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; SERPING1;
抗原和靶标
- P05155 IC1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASRLTLLTLLLLLLAGDRASSNPNATSSSSQDPESLQDRGEGKVATTVISKMLFVEPILEVSSLPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYPKDFTCVHQALKGFTTKGVTSVSQIFHSPDLAIRDTFVNASRTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWKTTFDPKKTRMEPFHFKNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVPQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFDFSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVARTLLVFEVQQPFLFVLWDQQHKFPVFMGRVYDPRA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P05155 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R4 | Methylation | Uniprot | |
| N25 | N-Glycosylation | Uniprot | |
| T47 | O-Glycosylation | Uniprot | |
| T48 | O-Glycosylation | Uniprot | |
| S64 | O-Glycosylation | Uniprot | |
| N69 | N-Glycosylation | Uniprot | |
| T71 | O-Glycosylation | Uniprot | |
| N81 | N-Glycosylation | Uniprot | |
| T83 | O-Glycosylation | Uniprot | |
| T88 | O-Glycosylation | Uniprot | |
| T92 | O-Glycosylation | Uniprot | |
| T96 | O-Glycosylation | Uniprot | |
| N238 | N-Glycosylation | Uniprot | |
| N253 | N-Glycosylation | Uniprot | |
| Y294 | Phosphorylation | Uniprot | |
| S296 | Phosphorylation | Uniprot | |
| K316 | Acetylation | Uniprot | |
| K321 | Acetylation | Uniprot | |
| N352 | N-Glycosylation | Uniprot | |
| S375 | Phosphorylation | Uniprot | |
| S460 | Phosphorylation | Uniprot |
研究背景
Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
Highly glycosylated (49%) with N- and O-glycosylation. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-25: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).
Can be proteolytically cleaved by E.coli stcE.
Secreted.
Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Interacts with MASP1.
Belongs to the serpin family.
研究领域
· Human Diseases > Infectious diseases: Bacterial > Pertussis.
· Organismal Systems > Immune system > Complement and coagulation cascades. (View pathway)
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