| 产品: | KCNQ5 抗体 |
| 货号: | DF4322 |
| 描述: | Rabbit polyclonal antibody to KCNQ5 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 预测: | Horse, Sheep, Rabbit, Dog |
| 分子量: | 100 KD; 102kD(Calculated). |
| 蛋白号: | Q9NR82 |
| RRID: | AB_2836690 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4322, RRID:AB_2836690.
展开/折叠
KCNQ 5; KCNQ5; KCNQ5_HUMAN; KQT like 5; KQT-like 5; Kv7.5; OTTHUMP00000064152; OTTHUMP00000064153; Potassium channel alpha subunit KvLQT5; Potassium channel protein; Potassium channel subunit alpha KvLQT5; Potassium voltage gated channel KQT like subfamily member 5; Potassium voltage gated channel subfamily KQT member 5; Potassium voltage-gated channel subfamily KQT member 5; Voltage gated potassium channel subunit Kv7.5; Voltage-gated potassium channel subunit Kv7.5;
抗原和靶标
Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus.
- Q9NR82 KCNQ5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLLGKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWKPHLKALHTCSPTKKEQGEASSSQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQPKPVIDADTALGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQITSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQTSDYQSPVDSKDLSGSAQNSGCLSRSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSAVAATNTIANQINTAPKPAAPTTLQIPPPLPAIKHLPRPETLHPNPAGLQESISDVTTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTEELNIQLSGSESSGSRGSQDFYPKWRESKLFITDEEVGPEETETDTFDAAPQPAREAAFASDSLRTGRSRSSQSICKAGESTDALSLPHVKLK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9NR82 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T67 | Phosphorylation | Uniprot | |
| S78 | Phosphorylation | Uniprot | |
| S88 | Phosphorylation | Uniprot | |
| Y96 | Phosphorylation | Uniprot | |
| S263 | Phosphorylation | Uniprot | |
| S447 | Phosphorylation | Uniprot | |
| S457 | Phosphorylation | Uniprot | |
| T459 | Phosphorylation | Uniprot | |
| S464 | Phosphorylation | Uniprot | |
| S466 | Phosphorylation | Uniprot | |
| Y500 | Phosphorylation | Uniprot | |
| T581 | Phosphorylation | Uniprot | |
| S618 | Phosphorylation | Uniprot | |
| K619 | Ubiquitination | Uniprot | |
| Y657 | Phosphorylation | Uniprot | |
| S807 | Phosphorylation | Uniprot | |
| S831 | Phosphorylation | Uniprot | |
| Y861 | Phosphorylation | Uniprot | |
| K863 | Acetylation | Uniprot | |
| S902 | Phosphorylation | Uniprot |
研究背景
Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1.
Cell membrane>Multi-pass membrane protein.
Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus.
Heteromultimer with KCNQ3. Heterotetramer with KCNQ1; has a voltage-gated potassium channel activity.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily.
研究领域
· Organismal Systems > Nervous system > Cholinergic synapse.
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