产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4411, RRID:AB_2836766.
展开/折叠
2010200P20Rik; AI194294; AL022976; BOS_25229; DKFZp313B211; MGC143331; OTTHUMP00000024037; OTTMUSP00000019067; RAP2C; RAP2C, member of RAS oncogene family; RAP2C_HUMAN; Ras related protein Rap 2c; Ras-related protein Rap-2c; RP23-15D12.2;
抗原和靶标
Expressed in liver, skeletal muscle, prostate, uterus, rectum, stomach, and bladder and to a lower extent in brain, kidney, pancreas, and bone marrow. Expressed in mononuclear leukocytes and megakaryocytes.
- Q9Y3L5 RAP2C_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDLEPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTTCVVQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9Y3L5 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y4 | Phosphorylation | Uniprot | |
| K5 | Ubiquitination | Uniprot | |
| S11 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| T20 | Phosphorylation | Uniprot | |
| T25 | Phosphorylation | Uniprot | |
| T27 | Phosphorylation | Uniprot | |
| K31 | Ubiquitination | Uniprot | |
| Y40 | Phosphorylation | Uniprot | |
| K42 | Ubiquitination | Uniprot | |
| T61 | Phosphorylation | Uniprot | |
| S66 | Phosphorylation | Uniprot | |
| Y106 | Phosphorylation | Uniprot | |
| K108 | Ubiquitination | Uniprot | |
| K117 | Ubiquitination | Uniprot | |
| K148 | Ubiquitination | Uniprot | |
| Y166 | Phosphorylation | Uniprot |
研究背景
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.
Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK.
Cytoplasm. Recycling endosome membrane>Lipid-anchor>Cytoplasmic side.
Expressed in liver, skeletal muscle, prostate, uterus, rectum, stomach, and bladder and to a lower extent in brain, kidney, pancreas, and bone marrow. Expressed in mononuclear leukocytes and megakaryocytes.
Belongs to the small GTPase superfamily. Ras family.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Tight junction. (View pathway)
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