| 产品: | PPP2R5D 抗体 |
| 货号: | DF4483 |
| 描述: | Rabbit polyclonal antibody to PPP2R5D |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 70 KD; 70kD(Calculated). |
| 蛋白号: | Q14738 |
| RRID: | AB_2836834 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4483, RRID:AB_2836834.
展开/折叠
2A5D_HUMAN; B'delta; B56D; Delta isoform of regulatory subunit B56, protein phosphatase 2A; MGC2134; MGC8949; OTTHUMP00000039821; PP2A B subunit B' delta isoform; PP2A B subunit B56 delta isoform; PP2A B subunit isoform B''-delta; PP2A B subunit isoform B56-delta; PP2A B subunit isoform PR61-delta; PP2A B subunit isoform R5-delta; PP2A B subunit PR61 delta isoform; PP2A B subunit R5 delta isoform; PPP2R5D; Protein phosphatase 2 regulatory subunit B (B56) delta isoform; Protein phosphatase 2 regulatory subunit B delta isoform; Protein phosphatase 2 regulatory subunit B' delta; Serine threonine protein phosphatase 2A 56 kDa regulatory subunit delta isoform; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform; TEG-271; Tex271;
抗原和靶标
Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain.
- Q14738 2A5D_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPYKLKKEKEPPKVAKCTAKPSSSGKDGGGENTEEAQPQPQPQPQPQAQSQPPSSNKRPSNSTPPPTQLSKIKYSGGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q14738 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T18 | Phosphorylation | Uniprot | |
| S54 | Phosphorylation | Uniprot | |
| S60 | Phosphorylation | P17612 (PRKACA) , O14757 (CHEK1) | Uniprot |
| S62 | Phosphorylation | Uniprot | |
| T63 | Phosphorylation | Uniprot | |
| T67 | Phosphorylation | Uniprot | |
| K71 | Ubiquitination | Uniprot | |
| K73 | Ubiquitination | Uniprot | |
| Y74 | Phosphorylation | Uniprot | |
| S75 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| K82 | Ubiquitination | Uniprot | |
| S88 | Phosphorylation | Uniprot | |
| S89 | Phosphorylation | Uniprot | |
| S90 | Phosphorylation | Uniprot | |
| S95 | Phosphorylation | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| S109 | Phosphorylation | Uniprot | |
| K121 | Ubiquitination | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| K232 | Ubiquitination | Uniprot | |
| K268 | Ubiquitination | Uniprot | |
| K332 | Ubiquitination | Uniprot | |
| K334 | Ubiquitination | Uniprot | |
| K367 | Ubiquitination | Uniprot | |
| K371 | Ubiquitination | Uniprot | |
| K409 | Ubiquitination | Uniprot | |
| Y451 | Phosphorylation | Uniprot | |
| T461 | Phosphorylation | Uniprot | |
| K479 | Ubiquitination | Uniprot | |
| Y488 | Phosphorylation | Uniprot | |
| K489 | Ubiquitination | Uniprot | |
| K500 | Ubiquitination | Uniprot | |
| K508 | Ubiquitination | Uniprot | |
| Y519 | Phosphorylation | Uniprot | |
| R523 | Methylation | Uniprot | |
| Y532 | Phosphorylation | Uniprot | |
| S533 | Phosphorylation | Uniprot | |
| T536 | Phosphorylation | Uniprot | |
| T538 | Phosphorylation | Uniprot | |
| K548 | Ubiquitination | Uniprot | |
| T553 | Phosphorylation | Uniprot | |
| K560 | Ubiquitination | Uniprot | |
| K572 | Ubiquitination | Uniprot | |
| S573 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| Y580 | Phosphorylation | Uniprot | |
| T581 | Phosphorylation | Uniprot | |
| K583 | Ubiquitination | Uniprot | |
| K589 | Ubiquitination | Uniprot | |
| S598 | Phosphorylation | Uniprot |
研究背景
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Cytoplasm. Nucleus.
Note: Nuclear in interphase, nuclear during mitosis.
Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain.
PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGO1. Interacts with ADCY8.
Belongs to the phosphatase 2A regulatory subunit B56 family.
研究领域
· Cellular Processes > Cell growth and death > Oocyte meiosis. (View pathway)
· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > AMPK signaling pathway. (View pathway)
· Genetic Information Processing > Translation > mRNA surveillance pathway.
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
· Organismal Systems > Nervous system > Dopaminergic synapse.
限制条款
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