| 产品: | PPP2R3B 抗体 |
| 货号: | DF4485 |
| 描述: | Rabbit polyclonal antibody to PPP2R3B |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Pig, Zebrafish, Chicken, Xenopus |
| 分子量: | 70 KD; 65kD(Calculated). |
| 蛋白号: | Q9Y5P8 |
| RRID: | AB_2836836 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4485, RRID:AB_2836836.
展开/折叠
NY REN 8; NY REN 8 antigen; P2R3B_HUMAN; PP2A B'' subunit PR48; PP2A subunit B isoform PR48; PP2A subunit B PR48 isoform; PPP2R3B; PPP2R3L; PPP2R3LY; PR 48; PR48; Protein phosphatase 2 (formerly 2A) regulatory subunit B'' beta; Protein phosphatase 2 regulatory subunit B'' beta; Protein phosphatase 2A 48 kDa regulatory subunit; Serine/threonine protein phosphatase 2A 48kDa regulatory subunit B; Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta;
抗原和靶标
- Q9Y5P8 P2R3B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPPGKVLQPVLKMKVDELFLYWLSEASTQRMLQDCLRRIKAPGRDQPTPGDGEQPGAWPTAPLAAPRPSGLEPPGTPGPGPALPLGAASSPRNAPHVRGTRRSAGTRVVQTRKEEPLPPATSQSIPTFYFPRGRPQDSVNVDAVISKIESTFARFPHERATMDDMGLVAKACGCPLYWKGPLFYGAGGERTGSVSVHKFVAMWRKILQNCHDDAAKFVHLLMSPGCNYLVQEDFVPFLQDVVNTHPGLSFLKEASEFHSRYITTVIQRIFYAVNRSWSGRITCAELRRSSFLQNVALLEEEADINQLTEFFSYEHFYVIYCKFWELDTDHDLLIDADDLARHNDHALSTKMIDRIFSGAVTRGRKVQKEGKISYADFVWFLISEEDKKTPTSIEYWFRCMDLDGDGALSMFELEYFYEEQCRRLDSMAIEALPFQDCLCQMLDLVKPRTEGKITLQDLKRCKLANVFFDTFFNIEKYLDHEQKEQISLLRDGDSGGPELSDWEKYAAEEYDILVAEETAGEPWEDGFEAELSPVEQKLSALRSPLAQRPFFEAPSPLGAVDLYEYACGDEDLEPL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9Y5P8 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S90 | Phosphorylation | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| K147 | Ubiquitination | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| Y184 | Phosphorylation | Uniprot | |
| S348 | Phosphorylation | Uniprot | |
| T349 | Phosphorylation | Uniprot | |
| K350 | Ubiquitination | Uniprot | |
| S357 | Phosphorylation | Uniprot | |
| K452 | Ubiquitination | Uniprot | |
| K459 | Ubiquitination | Uniprot | |
| K483 | Ubiquitination | Uniprot |
研究背景
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Nucleus.
PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with N-terminal region of CDC6. Interacts with NOD2.
研究领域
· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > AMPK signaling pathway. (View pathway)
· Genetic Information Processing > Translation > mRNA surveillance pathway.
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
· Organismal Systems > Nervous system > Dopaminergic synapse.
限制条款
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