SIRPB1 Antibody - #DF4507

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产品: SIRPB1 抗体
货号: DF4507
描述: Rabbit polyclonal antibody to SIRPB1
应用: WB IF/ICC
文献验证: WB
反应: Human, Rat
分子量: 48 KD; 43kD(Calculated).
蛋白号: O00241
RRID: AB_2836858

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Rat
克隆:
Polyclonal
特异性:
SIRPB1 Antibody detects endogenous levels of total SIRPB1.
RRID:
AB_2836858
引用格式: Affinity Biosciences Cat# DF4507, RRID:AB_2836858.
偶联:
Unconjugated. 130
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CD172 antigen like family member B; CD172b; CD172b antigen; DKFZp686A05192; Signal regulatory protein beta 1; SIRP BETA 1; SIRP beta 1 isoform 3;

抗原和靶标

免疫原:
Uniprot:

O00241(SIRB1_HUMAN) >>Visit HPA database.

基因/基因ID:
SIRPB1(10326)
表达:
O00241 SIRB1_HUMAN:

Detected in monocytes and dendritic cells.

序列:
MPVPASWPHLPSPFLLMTLLLGRLTGVAGEDELQVIQPEKSVSVAAGESATLRCAMTSLIPVGPIMWFRGAGAGRELIYNQKEGHFPRVTTVSELTKRNNLDFSISISNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAVRATPEHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPAGDSVSYSIHSTARVVLTRGDVHSQVICEIAHITLQGDPLRGTANLSEAIRVPPTLEVTQQPMRAENQANVTCQVSNFYPRGLQLTWLENGNVSRTETASTLIENKDGTYNWMSWLLVNTCAHRDDVVLTCQVEHDGQQAVSKSYALEISAHQKEHGSDITHEAALAPTAPLLVALLLGPKLLLVVGVSAIYICWKQKA

翻译修饰 - O00241 作为底物

Site PTM Type Enzyme
K82 Ubiquitination
K97 Ubiquitination
Y119 Phosphorylation
K182 Ubiquitination
N244 N-Glycosylation

研究背景

功能:

Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP.

翻译修饰:

N-glycosylated.

细胞定位:

Cell membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Detected in monocytes and dendritic cells.

亚基结构:

Homodimer; disulfide-linked. Interacts with TYROBP. This interaction results in the recruitment of SYK.

研究领域

· Organismal Systems > Development > Osteoclast differentiation.   (View pathway)

文献引用

1). Suppression of CHOP Reduces Neuronal Apoptosis and Rescues Cognitive Impairment Induced by Intermittent Hypoxia by Inhibiting Bax and Bak Activation. Neural Plasticity, 2021 (PubMed: 34471408) [IF=3.0]

Application: WB    Species: Mouse    Sample: hippocampus tissue

Figure 1 The PERK pathway but not the ATF-6 or IRE-1 pathway was activated. (a) The expression levels of p-PERK, p-elf2α, and ATF-4 were increased in the hippocampus after 2 weeks of IH exposure (n = 4). The expression of p-IRE1 (b) and p-ATF-6 (c) was not altered (n = 4). ∗P < 0.05; ∗∗P < 0.01; ns: not significant.

Application: WB    Species: mouse    Sample: hippocampal

Figure 1: |The PERK pathway but not the ATF-6 or IRE-1 pathway was activated. (a) The expression levels of p-PERK, p-elf2α, and ATF-4 were increased in the hippocampus after 2 weeks of IH exposure (n = 4). The expression of p-IRE1 (b) and p-ATF-6 (c) was not altered(n = 4). ∗P < 0:05; ∗∗P < 0:01; ns: not significant.

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