| 产品: | SLC4A11 抗体 |
| 货号: | DF4511 |
| 描述: | Rabbit polyclonal antibody to SLC4A11 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 分子量: | 100 KD; 100kD(Calculated). |
| 蛋白号: | Q8NBS3 |
| RRID: | AB_2836862 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4511, RRID:AB_2836862.
展开/折叠
Bicarbonate transporter related protein 1; Bicarbonate transporter-related protein 1; BTR1; CDPD; CHED2; Corneal endothelial dystrophy 2 autosomal recessive; dJ794I6.2; FECD4; MGC126418; MGC126419; NaBC1; S4A11_HUMAN; Slc4a11; Sodium bicarbonate transporter-like protein 11; Sodium borate cotransporter 1; Sodium coupled borate cotransporter 1; Solute carrier family 4 member 11; Solute carrier family 4 sodium bicarbonate transporter like member 11; Solute carrier family 4 sodium borate transporter member 11;
抗原和靶标
Widely expressed. Highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Not detected in retina and lymphocytes.
- Q8NBS3 S4A11_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSQVGGRGDRCTQEVQGLVHGAGDLSASLAENSPTMSQNGYFEDSSYYKCDTDDTFEAREEILGDEAFDTANSSIVSGESIRFFVNVNLEMQATNTENEATSGGCVLLHTSRKYLKLKNFKEEIRAHRDLDGFLAQASIVLNETATSLDNVLRTMLRRFARDPDNNEPNCNLDLLMAMLFTDAGAPMRGKVHLLSDTIQGVTATVTGVRYQQSWLCIICTMKALQKRHVCISRLVRPQNWGENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDIAFRQKLLETRTEEEFKEALVHQRQLLTMVSHGPVAPRTKERSTVSLPAHRHPEPPKCKDFVPFGKGIREDIARRFPLYPLDFTDGIIGKNKAVGKYITTTLFLYFACLLPTIAFGSLNDENTDGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLALYIQVIRVICDDYDLDFNSFYAWTGLWNSFFLALYAFFNLSLVMSLFKRSTEEIIALFISITFVLDAVKGTVKIFWKYYYGHYLDDYHTKRTSSLVSLSGLGASLNASLHTALNASFLASPTELPSATHSGQATAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVREILSDCALPIAVLAFSLISSHGFREIEMSKFRYNPSESPFAMAQIQSLSLRAVSGAMGLGFLLSMLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEERVENGHIYDTIVNVKETRLTSLGASVLVGLSLLLLPVPLQWIPKPVLYGLFLYIALTSLDGNQLVQRVALLLKEQTAYPPTHYIRRVPQRKIHYFTGLQVLQLLLLCAFGMSSLPYMKMIFPLIMIAMIPIRYILLPRIIEAKYLDVMDAEHRP
翻译修饰 - Q8NBS3 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S74 | Phosphorylation | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| T271 | Phosphorylation | Uniprot | |
| S277 | Phosphorylation | Uniprot | |
| K284 | Ubiquitination | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| T306 | Phosphorylation | Uniprot | |
| S309 | Phosphorylation | Uniprot | |
| T317 | Phosphorylation | Uniprot | |
| K344 | Ubiquitination | Uniprot | |
| K635 | Ubiquitination | Uniprot | |
| K752 | Ubiquitination | Uniprot | |
| K810 | Ubiquitination | Uniprot | |
| Y820 | Phosphorylation | Uniprot | |
| K880 | Ubiquitination | Uniprot |
研究背景
Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (By similarity). Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter.
Glycosylated.
Cell membrane. Membrane>Multi-pass membrane protein.
Widely expressed. Highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Not detected in retina and lymphocytes.
Homodimer.
Belongs to the anion exchanger (TC 2.A.31) family.
限制条款
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